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1. WO2020067868 - USE OF CD38 ENZYME INHIBITORS IN HIV-POSITIVE PATIENTS

Publication Number WO/2020/067868
Publication Date 02.04.2020
International Application No. PCT/MX2019/050020
International Filing Date 19.09.2019
IPC
A61P 31/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
A61K 31/352 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
CPC
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 36/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 45/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
Applicants
  • INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS ISMAEL COSIO VILLEGAS [MX]/[MX]
Inventors
  • ESPINOSA ARCINIEGA, Héctor Enrique
Agents
  • URIBE NAVARRETE, Rosa Mayela
Priority Data
MX/a/2018/01169826.09.2018MX
Publication Language Spanish (ES)
Filing Language Spanish (ES)
Designated States
Title
(EN) USE OF CD38 ENZYME INHIBITORS IN HIV-POSITIVE PATIENTS
(ES) USO DE INHIBIDORES ENZIMÁTICOS DE CD38 EN PACIENTES VIH POSITIVOS
(FR) UTILISATION D'INHIBITEURS ENZYMATIQUES DE CD38 CHEZ DES PATIENTS POSITIFS AU VIH
Abstract
(EN)
The invention relates to the use of CD38-inhibitor anthocyanins for producing a medicament for treating HIV infection. This second use is derived from the reconceptualisation of the role of CD38 as a biologically functional enzyme, supported by experimental tests that show how catalytic inhibition reduces the death of CD4 T cells and increases the capacity of same to differentiate into effector memory cells. These effects support homeostatic functions that are crucial in the regeneration of the immune system. Catalytic inhibitors come from berries, in particular, kuromanin, luteolin and luteolinidin, or traditional Mexican food such as blue corn, and can be used to inhibit the expression of CD38 even at basal levels.
(ES)
La presente invención proporciona el uso de antocianinas inhibidoras de CD38 para la elaboración de un medicamento para el tratamiento de la infección por VIH. Este segundo uso se deriva de la reconceptualización del rol de CD38 como una enzima biológicamente funcional, sustentado mediante ensayos experimentales que muestran como la inhibición catalítica disminuye la muerte de células T CD4 y aumenta la capacidad de éstas de diferenciarse a células de memoria efectoras. Estos efectos soportan funciones homeostáticas cruciales en la regeneración del sistema inmune. Los inhibidores catalíticos provienen de berries, en particular, éstos son la kuromanina, la luteolina y la luteolinidina; o alimentos tradicionales mexicanos, como el maíz azul, y son útiles para inhibir la expresión de CD38 incluso hasta a niveles basales.
(FR)
La présente invention concerne l'utilisation d'antocyanines inhibitrices de CD38 pour l'élaboration d'un médicament pour le traitement de l'infection par le VIH. Cette seconde utilisation provient de la reconceptualisation du rôle de CD38 comme enzyme biologiquement fonctionnelle, fondé sur des essais expérimentaux qui montrent que l'inhibition catalytique diminue la mort des lymphocytes T CD4 et augmente la capacité de ceux-ci à se différencier de cellules mémoires effectrices. Ces effets supportent des fonctions homéostatiques cruciales dans la régénération du système immunitaire. Les inhibiteurs catalytiques proviennent de baies, notamment, la kuromanine, la lutéoline et la lutéolinidine; ou d'aliments traditionnels mexicains, tels que le maïs bleu, et sont utiles pour inhiber l'expression de CD38 y compris jusqu'à des niveaux de base.
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