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1. WO2020067774 - SYNOVIUM-DERIVED MESENCHYMAL STEM CELLS AND USE THEREOF

Publication Number WO/2020/067774
Publication Date 02.04.2020
International Application No. PCT/KR2019/012602
International Filing Date 27.09.2019
IPC
C12N 5/0775 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775Mesenchymal stem cells; Adipose-tissue derived stem cells
A61K 35/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
CPC
A61K 35/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
Applicants
  • 주식회사 히에라바이오 HIERABIO INC. [KR]/[KR]
  • 인제대학교 산학협력단 INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 이승진 LEE, Seung Jin
  • 김희정 KIM, Heejung
  • 양영일 YANG, Young-Il
Agents
  • 손민 SON, Min
Priority Data
10-2018-011649628.09.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) SYNOVIUM-DERIVED MESENCHYMAL STEM CELLS AND USE THEREOF
(FR) CELLULES SOUCHES MÉSENCHYMATEUSES DÉRIVÉES DE LA SYNOVIALE ET LEUR UTILISATION
(KO) 활액막 유래 중간엽 줄기세포 및 그의 용도
Abstract
(EN)
The present invention relates to a method for producing synovium-derived mesenchymal stem cells using synovial tissue and hydrogel, synovium-derived mesenchymal stem cells produced using the method, a pharmaceutical composition for treating bone or cartilage damage, comprising the synovium-derived mesenchymal stem cells, and a composition and kit for culturing mesenchymal stem cells, which comprise synovial tissue and hydrogel. When the production method of the present invention is used, stem cells can be obtained by effective extraction from the synovium, and synovium-derived mesenchymal stem cells obtained using same can effectively treat bone or cartilage damage, and thus can greatly contribute to methods for treating bone or cartilage damage.
(FR)
La présente invention concerne un procédé de production de cellules souches mésenchymateuses dérivées de la synoviale à l'aide de tissu synovial et d'hydrogel, des cellules souches mésenchymateuses dérivées de la synoviale produites à l'aide du procédé, une composition pharmaceutique pour traiter les dommages osseux ou cartilagineux, comprenant les cellules souches mésenchymateuses dérivées de la synoviale, et une composition et un kit pour cultiver des cellules souches mésenchymateuses, qui comprend du tissu synovial et de l'hydrogel. Lorsque le procédé de production de la présente invention est utilisé, des cellules souches peuvent être obtenues par extraction efficace à partir de la synoviale, et des cellules souches mésenchymateuses dérivées de la synoviale obtenues à l'aide de celui-ci peuvent traiter efficacement les dommages osseux ou cartilagineux, et peuvent ainsi contribuer fortement aux méthodes de traitement des dommages osseux ou cartilagineux.
(KO)
본 발명은 활액막 조직과 하이드로젤을 이용하여 활액막 유래 중간엽줄기세포를 제조하는 방법, 상기 방법으로 제조된 활액막 유래 중간엽줄기세포, 상기 활액막 유래 중간엽줄기세포를 포함하는 골 또는 연골손상 치료용 약학 조성물, 활액막 조직 및 하이드로젤을 포함하는 중간엽 줄기세포 배양용 조성물 및 키트에 관한 것이다. 본 발명의 제조방법을 사용하면, 활액막으로부터 줄기세포를 효과적으로 추출하여 수득할 수 있고, 이처럼 수득한 활액막 유래 중간엽줄기세포는 골 또는 연골손상을 효과적으로 치료할 수 있으므로, 골 또는 연골의 손상을 치료하는 방법에 크게 기여할 수 있을 것이다.
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