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1. WO2020067501 - OVARIAN TISSUE TRANSPLANTATION METHOD AND FOLLICLE ACTIVATION METHOD

Publication Number WO/2020/067501
Publication Date 02.04.2020
International Application No. PCT/JP2019/038351
International Filing Date 27.09.2019
IPC
A61K 35/54 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
A61K 9/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor
A61K 38/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
24Follicle-stimulating hormone ; Chorionic gonadotropins, e.g. HCG; Luteinising hormone ; Thyroid-stimulating hormone
A61K 47/42 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61L 27/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
22Polypeptides or derivatives thereof
24Collagen
A61L 27/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
CPC
A61K 35/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
A61K 38/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
24Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
A61K 47/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61K 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor; ; Other semi-solid forms, e.g. creams, sticks, gels
A61L 27/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
14Macromolecular materials
22Polypeptides or derivatives thereof ; , e.g. degradation products
24Collagen
A61L 27/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
Applicants
  • 株式会社北里コーポレーション KITAZATO CORPORATION [JP]/[JP]
Inventors
  • 河村 和弘 KAWAMURA Kazuhiro
  • 佐藤 可野 SATO Yorino
Agents
  • 星野 裕司 HOSHINO Hiroshi
Priority Data
2018-18302727.09.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) OVARIAN TISSUE TRANSPLANTATION METHOD AND FOLLICLE ACTIVATION METHOD
(FR) MÉTHODE DE TRANSPLANTATION DE TISSU OVARIEN ET MÉTHODE D'ACTIVATION FOLLICULAIRE
(JA) 卵巣組織の移植方法および卵胞活性化方法
Abstract
(EN)
The present invention prevents clumping of ovarian tissue fragments, promotes angiogenesis, and improves take rate when transplanting a plurality of ovarian tissue fragments. When transplanting a plurality of ovarian tissue fragments, formed by thinly slicing ovarian tissue, to a mammal, the ovarian tissue fragments are transplanted via an injection step of injecting a collagen gel having a gel concentration of approximately 1% into the scheduled transplantation site, and a transplantation step of subsequently inserting the plurality of ovarian tissue fragments into the collagen gel. At such time, the plurality of ovarian tissue fragments may each be encapsulated in collagen gel in advance.
(FR)
La présente invention empêche l'agglutination de fragments de tissu ovarien, stimule l'angiogenèse, et améliore le taux de prise lors de la transplantation d'une série de fragments de tissu ovarien. Lors de la transplantation à un mammifère d'une série de fragments de tissu ovarien, formés en coupant finement du tissu ovarien, les fragments de tissu ovarien sont transplantés par l'intermédiaire d'une étape d'injection consistant à injecter, au niveau du site de transplantation planifié, un gel de collagène présentant une concentration de gel d'environ 1 %, suivie d'une étape de transplantation consistant à insérer par la suite la série de fragments de tissu ovarien dans le gel de collagène. À cette étape, les fragments de tissu ovarien peuvent chacun être encapsulés dans le gel de collagène à l'avance.
(JA)
複数の卵巣組織断片を移植する際に、卵巣組織断片の集塊を防ぎ血管新生を促進させ、生着率を向上させる。卵巣組織を細切することにより形成された複数の卵巣組織断片を哺乳動物に移植する際に、ゲル濃度1%程度のコラーゲンゲルを用い、移植予定部位にコラーゲンゲルを注入する注入工程と、その後、複数の前記卵巣組織断片を前記コラーゲンゲル内に挿入する移植工程と、によって卵巣組織断片を移植する。このとき、複数の卵巣組織断片の夫々を予めコラーゲンゲルで被包するようにしても良い。
Also published as
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