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1. WO2020067485 - INDUCER OF CARDIAC ABILITY TO SYNTHESIZE ACETYLCHOLINE

Publication Number WO/2020/067485
Publication Date 02.04.2020
International Application No. PCT/JP2019/038293
International Filing Date 27.09.2019
IPC
C07C 381/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
381Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/-C07C337/142
A61K 31/198 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C07C 381/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
381Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
Applicants
  • 学校法人日本医科大学 NIPPON MEDICAL SCHOOL FOUNDATION [JP]/[JP]
Inventors
  • 柿沼 由彦 KAKINUMA Yoshihiko
  • 中村 成夫 NAKAMURA Shigeo
Agents
  • 棚井 澄雄 TANAI Sumio
  • 小林 淳一 KOBAYASHI Junichi
  • 土屋 亮 TSUCHIYA Ryo
  • 服部 映美 HATTORI Emi
Priority Data
2018-18511228.09.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) INDUCER OF CARDIAC ABILITY TO SYNTHESIZE ACETYLCHOLINE
(FR) INDUCTEUR DE LA CAPACITÉ CARDIAQUE À SYNTHÉTISER L'ACÉTYLCHOLINE
(JA) 心臓アセチルコリン産生能誘導薬
Abstract
(EN)
A compound represented by formula (1), a salt thereof or a solvate of the same [in formula (1), R1 represents a linear or branched alkyl group having 2 to 10 carbon atoms, a linear or branched alkyl group having 1 to 10 carbon atoms in which one or more hydrogen atoms are substituted by carboxy groups, or an aryl group having 6 to 20 carbon atoms, each group being optionally substituted].
(FR)
L'invention concerne un composé représenté par la formule (1), un sel de celui-ci ou un solvate de celui-ci [dans la formule (1), R1 représente un groupe alkyle linéaire ou ramifié ayant 2 à 10 atomes de carbone, un groupe alkyle linéaire ou ramifié ayant 1 à 10 atomes de carbone dans lequel un ou plusieurs atomes d'hydrogène sont substitués par des groupes carboxy, ou un groupe aryle ayant 6 à 20 atomes de carbone, chaque groupe étant éventuellement substitué].
(JA)
下記式(1)で表される化合物若しくはその塩又はそれらの溶媒和物(式(1)中、Rは、いずれも置換されていてもよい、炭素数2~10の直鎖状又は分岐鎖状のアルキル基、1個又は複数個の水素原子がカルボキシ基に置換されている直鎖状又は分岐鎖上の炭素数1~10のアルキル基又は炭素数6~20のアリール基を表す。)。
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