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1. WO2020067439 - SHEETING METHOD FOR CARDIOMYOCYTES

Publication Number WO/2020/067439
Publication Date 02.04.2020
International Application No. PCT/JP2019/038192
International Filing Date 27.09.2019
IPC
C12N 5/0735 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
073Embryonic cells or tissues; Foetal cells or tissues
0735Embryonic stem cells; Embryonic germ cells
A61K 35/34 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
34Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
A61L 27/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
38Animal cells
A61P 9/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 41/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
41Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
C12N 5/077 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
CPC
A61K 35/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
34Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
A61K 35/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
A61L 27/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
A61P 41/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
41Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
A61P 9/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
3Tissue, human, animal or plant cell, or virus culture apparatus
Applicants
  • 国立大学法人大阪大学 OSAKA UNIVERSITY [JP]/[JP]
  • テルモ株式会社 TERUMO KABUSHIKI KAISHA [JP]/[JP]
Inventors
  • 澤 芳樹 SAWA, Yoshiki
  • 宮川 繁 MIYAGAWA, Shigeru
  • 大山 賢二 OYAMA, Kenji
  • 大橋 文哉 OHASHI, Fumiya
Agents
  • 葛和 清司 KUZUWA, Kiyoshi
Priority Data
2018-18244327.09.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) SHEETING METHOD FOR CARDIOMYOCYTES
(FR) PROCÉDÉ DE GAINAGE POUR CARDIOMYOCYTES
(JA) 心筋細胞のシート化方法
Abstract
(EN)
The purpose of the present invention is to provide: a method for producing a high-quality graft, such as a sheet-shaped cell culture, that includes a variety of iPS cell-derived cells, such as cardiomyocytes, while possessing the functions of the cells to a high degree; a graft produced by using the method; and a method for treating a disease by using the graft. The problem is solved by a method for producing a graft, the method comprising: (a) a step for inoculating a cell population that includes cells differentiation-induced from an iPS cell onto a culture substrate, and (b) a step for performing a graft-forming cultivation of the inoculated cell population on a graft formation medium that includes a platelet lysate.
(FR)
Le but de la présente invention est de fournir un procédé de production d'un greffon de haute qualité, tel qu'une culture cellulaire en forme de feuille, comprenant une variété de cellules dérivées de cellules SPi, tels que des cardiomyocytes, tout en possédant les fonctions des cellules à un degré élevé; un greffon produit à l'aide dudit procédé; et un procédé de traitement d'une maladie à l'aide du greffon. La solution selon l'invention consiste à fournir un procédé de production d'un greffon, ledit procédé comprenant : (a) une étape d'inoculation d'une population de cellules qui comprend des cellules induites par différenciation à partir d'une cellule SPi sur un substrat de culture, et (b) une étape pour effectuer une culture de formation de greffon de la population de cellules inoculées sur un milieu de formation de greffon qui comprend un lysat plaquettaire.
(JA)
iPS細胞由来の種々の細胞、例えば心筋細胞、を該細胞の機能を高度に有したまま含み、高品質な移植片、例えばシート状細胞培養物、を製造する方法、当該方法を用いて製造された移植片、当該移植片を用いた疾患の処置方法などを提供することを目的とする。 (a)iPS細胞から分化誘導された細胞を含む細胞集団を、培養基材上に播種する工程、および(b)播種した細胞集団を、血小板溶解物を含む移植片形成媒体で移植片形成培養する工程を含む、移植片の製造方法などにより、上記課題が解決された。
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