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1. WO2020067419 - ANTIGEN-BINDING MOLECULES CAPABLE OF BINDING CD3 AND CD137 BUT NOT SIMULTANEOUSLY

Publication Number WO/2020/067419
Publication Date 02.04.2020
International Application No. PCT/JP2019/038138
International Filing Date 27.09.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12N 1/15 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
14Fungi ; Culture media therefor
15modified by introduction of foreign genetic material
C12N 1/19 2006.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
14Fungi ; Culture media therefor
16Yeasts; Culture media therefor
19modified by introduction of foreign genetic material
C12N 1/21 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
21modified by introduction of foreign genetic material
CPC
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12N 5/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
10Cells modified by introduction of foreign genetic material ; Not used, see subgroups
Applicants
  • CHUGAI SEIYAKU KABUSHIKI KAISHA [JP]/[JP]
Inventors
  • HO, Shu Wen Samantha
  • FENG, Shu
Agents
  • HARUNA, Masao
  • SHIMIZU, Hatsushi
  • YAMAGUCHI, Hirotaka
  • OSAKABE, Suguru
  • INOUE, Ryuichi
  • SATO, Toshimitsu
  • SHIMMI, Hirokazu
  • KOBAYASHI, Tomohiko
  • KODERA, Hideki
  • OHZEKI, Masato
  • IGARASHI, Yoshihiro
  • KAWAMOTO, Kazuya
Priority Data
2018-18512028.09.2018JP
2019-10430804.06.2019JP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIGEN-BINDING MOLECULES CAPABLE OF BINDING CD3 AND CD137 BUT NOT SIMULTANEOUSLY
(FR) MOLÉCULES DE LIAISON À L'ANTIGÈNE CAPABLES DE SE LIER À CD3 ET CD137 MAIS PAS SIMULTANÉMENT
Abstract
(EN)
The present invention relates to antigen-binding molecules binding to CD3 and CD137 (4-1BB); compositions comprising the antigen-binding molecule; and methods of using the same. The present invention provides antigen-binding molecules comprising: an antibody variable region that is capable of binding to CD3 and CD137 (4-1BB), but does not bind to CD3 and CD137 at the same time; and a variable region binding to a third antigen different from CD3 and CD137. Such antigen binding molecules exhibit enhanced T-cell dependent cytotoxity activity induced by these antigen-binding molecules through binding to the three different antigens.
(FR)
La présente invention concerne des molécules de liaison à l'antigène se liant à CD3 et CD137 (4-1BB) ; des compositions comprenant la molécule de liaison à l'antigène ; et des procédés d'utilisation de celles-ci. La présente invention concerne des molécules de liaison à l'antigène comprenant : une région variable d'anticorps qui est capable de se lier à CD3 et CD137 (4-1BB), mais ne se lie pas à CD3 et CD137 en même temps ; et une région variable se liant à un troisième antigène différent de CD3 et de CD137. De telles molécules de liaison à l'antigène présentent une activité de cytotoxité dépendante des lymphocytes T améliorée induite par ces molécules de liaison à l'antigène par liaison aux trois antigènes différents.
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