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1. WO2020066991 - MAMMAL CELL PRESERVING SOLUTION CONTAINING ACARBOSE OR STACHYOSE

Publication Number WO/2020/066991
Publication Date 02.04.2020
International Application No. PCT/JP2019/037223
International Filing Date 24.09.2019
IPC
C12N 1/04 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
04Preserving or maintaining viable microorganisms
A01N 1/02 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
A01N 63/00 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
63Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
C12N 5/071 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
C12N 5/074 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
074Adult stem cells
C12N 5/077 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
CPC
A01N 1/02
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
A01N 63/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
63Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
C12N 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof
04Preserving or maintaining viable microorganisms
Applicants
  • 株式会社大塚製薬工場 OTSUKA PHARMACEUTICAL FACTORY,INC. [JP]/[JP]
Inventors
  • 白川 智景 SHIRAKAWA, Chikage
  • 西村 益浩 NISHIMURA, Masuhiro
  • 土居 雅子 DOI, Masako
Agents
  • 廣田 雅紀 HIROTA, Masanori
Priority Data
2018-18477928.09.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) MAMMAL CELL PRESERVING SOLUTION CONTAINING ACARBOSE OR STACHYOSE
(FR) SOLUTION DE CONSERVATION DE CELLULES DE MAMMIFÈRES CONTENANT DE L'ACARBOSE OU DU STACHYOSE
(JA) アカルボース又はスタキオースを含む哺乳動物細胞保存用液
Abstract
(EN)
The present invention addresses the problem of providing a mammal cell preserving solution or the like which can effectively suppress cell viability reduction or cell aggregation occurring when mammal cells are preserved in a liquid, and which contains a substance that is less likely to have an adverse effect on the ecology of a mammal or contains a substance related thereto. By using a solution which contains acarbose or a salt thereof, and/or stachyose or a salt thereof to preserve mammal cells, cell viability reduction or cell aggregation which occur when mammal cells are preserved in a liquid can be effectively suppressed. Furthermore, the mammal cells preserved in the liquid can be directly administered into a mammal without being transferred to a new transplant solution.
(FR)
La présente invention aborde le problème consistant à fournir une solution de conservation de cellules de mammifères ou similaire qui peut supprimer efficacement la réduction de la viabilité cellulaire ou l'agrégation cellulaire se produisant lorsque des cellules de mammifères sont conservées dans un liquide, et qui contient une substance qui est moins susceptible d'avoir un effet indésirable sur l'écologie autour d'un mammifère ou qui contient une substance associée à celle-ci. En faisant appel à une solution qui contient de l'acarbose ou un sel de celui-ci et/ou du stachyose ou un sel de celui-ci pour conserver des cellules de mammifères, la réduction de la viabilité cellulaire ou l'agrégation cellulaire, qui se produisent lorsque des cellules de mammifères sont conservées dans un liquide, peuvent être efficacement supprimées. En outre, les cellules de mammifères conservées dans le liquide peuvent être administrées directement à un mammifère sans être transférées dans une nouvelle solution pour greffons.
(JA)
本発明は、哺乳動物細胞を液体中で保存したときに生じる細胞生存率低下や細胞凝集を効果的に抑制でき、かつ、哺乳動物の生体内に投与した場合に、哺乳動物の生態に悪影響を及ぼす可能性が低い物質や、かかる物質を含む哺乳動物細胞保存用液等を提供することを課題とする。 アカルボース若しくはその塩、及び/又はスタキオース若しくはその塩を含む液を、哺乳動物細胞を保存するために用いると、哺乳動物細胞を液体中に保存したときに生じる細胞生存率低下や細胞凝集を効果的に抑制することができる。さらに、上記液中で保存した哺乳動物細胞は、新しい移植用液に移すことなく、そのまま哺乳動物の生体内へ投与することができる。
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