Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020066818 - IN VITRO GROWTH METHOD FOR HAIR FOLLICULAR EPITHELIAL STEM CELLS

Publication Number WO/2020/066818
Publication Date 02.04.2020
International Application No. PCT/JP2019/036687
International Filing Date 19.09.2019
IPC
C12N 5/071 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
A61K 35/36 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
A61L 27/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
A61L 27/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
38Animal cells
A61L 27/60 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
60Materials for use in artificial skin
A61P 17/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
14for baldness or alopecia
CPC
A61K 35/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
A61L 27/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
A61L 27/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
A61L 27/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
50Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
60Materials for use in artificial skin
A61P 17/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
14for baldness or alopecia
Applicants
  • 株式会社オーガンテクノロジーズ ORGAN TECHNOLOGIES, INC. [JP]/[JP]
  • 京セラ株式会社 KYOCERA CORPORATION [JP]/[JP]
  • 国立研究開発法人理化学研究所 RIKEN [JP]/[JP]
Inventors
  • 辻 孝 TSUJI, Takashi
  • 浅川 杏祐 ASAKAWA, Kyosuke
  • 武尾 真 TAKEO, Makoto
  • 豊島 公栄 TOYOSHIMA, Koh-ei
  • 小川 美帆 OGAWA, Miho
  • 森 悠 MORI, Yutaka
  • 岸本 恭介 KISHIMOTO, Kyosuke
Agents
  • 南条 雅裕 NANJO, Masahiro
  • 瀬田 あや子 SETA, Ayako
  • 伊波 興一朗 IHA, Koichiro
  • 原 秀貢人 HARA, Hokuto
Priority Data
2018-17981626.09.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) IN VITRO GROWTH METHOD FOR HAIR FOLLICULAR EPITHELIAL STEM CELLS
(FR) PROCÉDÉ DE CROISSANCE IN VITRO DE CELLULES SOUCHES ÉPITHÉLIALES DE FOLLICULES PILEUX
(JA) 毛包上皮性幹細胞の生体外増殖方法
Abstract
(EN)
[Problem] To provide a means that is for efficient growth of epithelial cells and that can be used to produce regenerated hair follicle germs. [Solution] Provided is a culture medium that is for growing epithelial cells, that can be used to produce regenerated hair follicle germs, and that contains a basic culture medium and at least one of at least (1)-(3): (1) at least one BMP inhibitor; (2) at least one fibroblast growth factor; and (3) sonic hedgehog (SHH) or a SHH agonist. Also provided is a method for growing the epithelial cells using the culture medium.
(FR)
Le problème décrit par la présente invention est de fournir un moyen qui est destiné à une croissance efficace des cellules épithéliales et qui peut être utilisé pour produire des germes de follicules pileux régénérés. La solution selon l'invention porte sur un milieu de culture qui est destiné à la croissance des cellules épithéliales, qui peut être utilisé pour produire des germes de follicules pileux régénérés, et qui contient un milieu de culture basique et au moins l'un parmi au moins les composés (1) à (3) : (1) au moins un inhibiteur de BMP ; (2) au moins un facteur de croissance des fibroblastes ; et (3) une protéine sonic hedgehog (SHH) ou un agoniste de SHH. L'invention concerne également un procédé de culture des cellules épithéliales à l'aide du milieu de culture.
(JA)
【課題】 再生毛包原基の製造に使用することが可能な上皮性細胞を効率よく増殖するための手段を提供すること。 【解決手段】 再生毛包原基の製造に使用することが可能な上皮性細胞を増殖するための培養培地であって、基礎培地と、少なくとも以下の(1)~(3):(1)少なくとも1種のBMP阻害剤;(2)少なくとも1種の線維芽細胞増殖因子;および(3)ソニックヘッジホッグ(SHH)またはSHHアゴニスト、の少なくとも1種とを含む培養培地、および前記培養培地を用いた、前記上皮性細胞を増殖する方法が提供される。
Latest bibliographic data on file with the International Bureau