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1. WO2020066577 - THERAPEUTIC DRUG FOR PERIODONTAL DISEASE

Publication Number WO/2020/066577
Publication Date 02.04.2020
International Application No. PCT/JP2019/035433
International Filing Date 10.09.2019
IPC
A61K 31/197 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A61K 31/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
A61K 41/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61P 1/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 31/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
02Local antiseptics
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 31/197
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A61K 31/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
A61K 41/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 31/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
02Local antiseptics
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • 国立大学法人大阪大学 OSAKA UNIVERSITY [JP]/[JP]
  • SBIファーマ株式会社 SBI PHARMACEUTICALS CO., LTD. [JP]/[JP]
Inventors
  • 粟津 邦男 AWAZU, Kunio
  • 関根 伸一 SEKINE, Shinichi
  • 石塚 昌宏 ISHIZUKA, Masahiro
Agents
  • 廣田 雅紀 HIROTA, Masanori
Priority Data
2018-18047526.09.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) THERAPEUTIC DRUG FOR PERIODONTAL DISEASE
(FR) MÉDICAMENT THÉRAPEUTIQUE POUR PARODONTOPATHIE
(JA) 歯周病治療薬
Abstract
(EN)
The present invention addresses the problem of providing a therapeutic drug and a therapeutic method that enable photodynamic therapy (PDT) against periodontal disease-causing pathogenic microbes for which conventional PDTs are not effective. The present invention involves: administering, to a site affected by periodontal disease, a therapeutic drug, for periodontal disease, containing a compound represented by formula (I) (in the formula, R1 represents a hydrogen atom or an acyl group, R2 represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group) or a pharmaceutically acceptable salt thereof; and then irradiating the site with light having a wavelength of 360-700 nm.
(FR)
La présente invention aborde le problème de production d'un médicament thérapeutique et de mise en oeuvre d'une méthode thérapeutique qui permettent d'effectuer un traitement photodynamique (PDT) pour éradiquer des microbes pathogènes provoquant une parodontopathie pour lesquels des PDT classiques ne sont pas efficaces. La présente invention comprend : l'administration, sur un site affecté par une parodontopathie, d'un médicament thérapeutique, pour traiter une parodontopathie, contenant un composé représenté par la formule (I) (dans la formule, R1 représente un atome d'hydrogène ou un groupe acyle, R2 représente un atome d'hydrogène, un groupe alkyle, un groupe cycloalkyle, un groupe aryle ou un groupe aralkyle) ou un sel pharmaceutiquement acceptable de ce composé; puis l'irradiation du site par de la lumière ayant une longueur d'onde comprise entre 360 et 700 nm.
(JA)
本発明は、従来の光線動力学的治療法(PDT)では効力示さない歯周病病原菌に対してもPDTが可能となる治療薬及び治療方法を提供することを課題とする。 下記式(I) (式中、Rは、水素原子又はアシル基を表し、Rは、水素原子、アルキル基、シクロアルキル基、アリール基又はアラルキル基を表す。)で表される化合物又は薬学的に許容されるその塩を含む歯周病の治療薬を、歯周病患部に投与し、その後360nm~700nmの波長の光を照射する。
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