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1. WO2020066396 - CARDIOTOXICITY ASSESSMENT METHOD

Publication Number WO/2020/066396
Publication Date 02.04.2020
International Application No. PCT/JP2019/033022
International Filing Date 23.08.2019
IPC
C12Q 1/02 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
C12Q 1/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Applicants
  • 日本ゼオン株式会社 ZEON CORPORATION [JP]/[JP]
Inventors
  • 足達 慧 ADACHI Satoru
  • 関野 祐子 SEKINO Yuko
Agents
  • 杉村 憲司 SUGIMURA Kenji
Priority Data
2018-18553328.09.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) CARDIOTOXICITY ASSESSMENT METHOD
(FR) PROCÉDÉ D'ÉVALUATION DE CARDIOTOXICITÉ
(JA) 心毒性評価方法
Abstract
(EN)
This cardiotoxicity assessment method is for measuring a biomarker for heart disease with high precision. This cardiotoxicity assessment method comprises disseminating cardiac muscle cells together with a culture medium into a culture vessel, adding a drug to the medium in the culture vessel to bring the drug into contact with the cardiac muscle cells, and then measuring a heart disease biomarker secreted from the cardiac muscle cells, to assess the cardiotoxicity of the drug, wherein at least a culture surface of the culture vessel is made of an alicyclic structure-containing polymer, and the culture surface has a surface free energy of 30-37 mN/m.
(FR)
Ce procédé d'évaluation de la cardiotoxicité est destiné à mesurer un biomarqueur pour une maladie cardiaque avec une précision élevée. Ce procédé d'évaluation de la cardiotoxicité consiste à disséminer des cellules de muscle cardiaque conjointement avec un milieu de culture dans un récipient de culture, ajouter un médicament au milieu dans le récipient de culture pour amener le médicament en contact avec les cellules du muscle cardiaque puis mesurer un biomarqueur de maladie cardiaque secrété à partir des cellules de muscle cardiaque pour évaluer la cardiotoxicité du médicament, au moins une surface de culture du récipient de culture étant constituée d'un polymère contenant une structure alicyclique et la surface de culture ayant une énergie libre de surface de 30-37 mN/m.
(JA)
心疾患のバイオマーカーを高い精度で測定する心毒性評価方法。心筋細胞を培地とともに培養容器に播種し、前記培養容器内の培地に薬剤を添加して、該薬剤を前記心筋細胞に接触させ、その後、前記心筋細胞から分泌される心疾患のバイオマーカーを測定して前記薬剤の心毒性を評価する、心毒性評価方法であって、前記培養容器の少なくとも培養面が脂環構造含有重合体で構成され、かつ、前記培養面の表面自由エネルギーが30~37mN/mである、方法。
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