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1. WO2020065594 - IL-36 ANTIBODIES AND USES THEREOF

Publication Number WO/2020/065594
Publication Date 02.04.2020
International Application No. PCT/IB2019/058203
International Filing Date 27.09.2019
IPC
C07K 16/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
A61P 37/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
CPC
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07K 16/244
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
244Interleukins [IL]
C07K 16/465
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
461Igs containing Ig-regions, -domains or -residues form different species
464Igs containing CDR-residues from one specie grafted between FR-residues from another
465with additional modified FR-residues
C07K 2317/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
32specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
C07K 2317/33
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applicants
  • KYOWA KIRIN CO., LTD. [JP]/[JP]
Inventors
  • SACHEN, Kacey Layn
  • MCKNIGHT, Andrew John
  • NUGENT, Rachel Soloff
  • LAUDENSLAGER, John Lorca
  • DESTITO, Giuseppe
  • ZAJONC, Dirk Michael
  • BITRA, Aruna
  • YAMADA, Takenao
Agents
  • ISHIKAWA, Toru
Priority Data
62/739,07428.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IL-36 ANTIBODIES AND USES THEREOF
(FR) ANTICORPS IL-36 ET LEURS UTILISATIONS
Abstract
(EN)
An antibody or antigen binding fragment thereof that binds to an IL-36, wherein the antibody or antigen binding fragment thereof binds to both IL-36α and IL-36γ, and wherein the antibody is an antagonist of both IL-36α and IL-36γ.
(FR)
L'invention concerne un anticorps ou un fragment de liaison à l'antigène de celui-ci qui se lie à IL-36, l'anticorps ou un fragment de liaison à l'antigène de celui-ci se liant à la fois à IL-36α et à IL-36γ, et l'anticorps étant un antagoniste de l'IL-36α et de l'IL-36γ.
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