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1. WO2020065349 - VACCINES AND METHODS

Publication Number WO/2020/065349
Publication Date 02.04.2020
International Application No. PCT/GB2019/052747
International Filing Date 27.09.2019
IPC
A61K 39/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C07K 16/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
A61P 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
CPC
A61K 2039/525
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
C07K 14/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
C07K 16/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
06from serum
C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
Applicants
  • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE [GB]/[GB]
  • UNIVERSITY OF WESTMINSTER [GB]/[GB]
  • UNIVERSITAT REGENSBURG [DE]/[DE]
Inventors
  • HEENEY, Jonathan Luke
  • FROST, Simon
  • ASBACH, Benedikt
  • KINGSLEY, Rebecca
  • WRIGHT, Edward
Agents
  • THORNTON, Neil
Priority Data
1815956.628.09.2018GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VACCINES AND METHODS
(FR) VACCINS ET MÉTHODES
Abstract
(EN)
Methods for identifying optimized antigenic pathogen polypeptides capable of inducing a broadly neutralizing immune response, and associated T-cell responses, to a pathogen are described, as well as nucleic acid sequences encoding such polypeptides. Methods for determining whether a broadly neutralizing immune response is induced in a subject following immunization with an optimized antigenic pathogen polypeptide, or a nucleic acid encoding the optimized pathogen polypeptide, are also described. Nucleic acid molecules, polypeptides, vectors, cells, fusion proteins, pharmaceutical compositions, and their use as vaccines against pathogens, especially against emerging or re-emerging pathogens (particularly RNA viruses), are also described.
(FR)
L'invention concerne des méthodes d'identification de polypeptides pathogènes antigéniques optimisés permettant d'induire une réponse immunitaire neutralisante à large spectre, et des réponses de lymphocytes T associées, contre un pathogène, ainsi que des séquences d'acides nucléiques codant pour de tels polypeptides. L'invention concerne également des procédés permettant de déterminer si une réponse immunitaire neutralisante à large spectre est induite chez un sujet après l'immunisation avec un polypeptide pathogène antigénique optimisé, ou un acide nucléique codant pour le polypeptide pathogène optimisé. L'invention concerne également des molécules d'acides nucléiques, des polypeptides, des vecteurs, des cellules, des protéines de fusion, des compositions pharmaceutiques et leur utilisation en tant que vaccins contre des pathogènes, en particulier contre des pathogènes émergents ou ré-émergents (en particulier des virus à ARN).
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