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1. WO2020064479 - α2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA

Publication Number WO/2020/064479
Publication Date 02.04.2020
International Application No. PCT/EP2019/075102
International Filing Date 19.09.2019
IPC
A61K 31/496 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • BAYER AKTIENGESELLSCHAFT [DE]/[DE]
Inventors
  • DELBECK, Martina
  • HAHN, Michael
Agents
  • BIP PATENTS
Priority Data
18196686.225.09.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) α2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA
(FR) ANTAGONISTES DE RÉCEPTEUR ALPHA 2-ADRÉNERGIQUES DE SOUS-TYPE C (ALPHA-2C) POUR LE TRAITEMENT DE L'APNÉE DU SOMMEIL
Abstract
(EN)
The present invention relates to α2 -Adrenoceptor subtype C (alpha-2C) antagonists, in particular aryl piperazines of formula (I) for the use in a method for the treatment and/or prophylaxis of sleep-related breathing disorders, preferably obstructive and central sleep apneas and snoring.
(FR)
La présente invention concerne des antagonistes de récepteur alpha 2-adrénergiques de sous-type C (alpha-2C), en particulier des arylpipérazines de formule (I) utilisées dans un procédé de traitement et/ou de prophylaxie de troubles respiratoires liés au sommeil, de préférence d'apnée obstructive du sommeil, d'apnée centrale du sommeil ou de ronflement.
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