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1. WO2020064173 - INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION

Publication Number WO/2020/064173
Publication Date 02.04.2020
International Application No. PCT/EP2019/070115
International Filing Date 25.07.2019
IPC
C07D 277/64 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
60condensed with carbocyclic rings or ring systems
62Benzothiazoles
64with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61K 31/428 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
428condensed with carbocyclic rings
CPC
A61K 31/428
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
428condensed with carbocyclic rings
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07D 277/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
60condensed with carbocyclic rings or ring-systems
62Benzothiazoles
64with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
Applicants
  • ANTABIO SAS [FR]/[FR]
Inventors
  • LEIRIS, Simon
  • DAVIES, David Thomas
  • EVERETT, Martin
  • SPRYNSKI, Nicolas
  • BEYRIA, Lilha
  • PALLIN, Thomas David
  • CRIDLAND, Andrew Peter
  • BLENCH, Toby Jonathan
  • ELLIOTT, Richard Leonard
  • CLARK, David Edward
Agents
  • J A KEMP LLP
Priority Data
18197365.227.09.2018EP
18290104.126.09.2018EP
18290106.625.09.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION
(FR) DÉRIVÉS D'INDANE DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT D'UNE INFECTION BACTÉRIENNE
Abstract
(EN)
The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, n and p are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.
(FR)
L'invention concerne un composé qui est un indane selon la formule (I), ou un sel pharmaceutiquement acceptable de celui-ci, dans laquelle R1, R2, R3, R4, R5, R6, n et p sont tels que définis dans la description. Ces composés sont utiles dans le traitement d'une infection antibactérienne soit comme antibiotiques seuls, soit en association avec d'autres antibiotiques.
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