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1. WO2020063965 - PYRAZOLOPYRIMIDINE DERIVATIVE AS SELECTIVE TRK INHIBITOR

Publication Number WO/2020/063965
Publication Date 02.04.2020
International Application No. PCT/CN2019/109043
International Filing Date 29.09.2019
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 南京明德新药研发有限公司 MEDSHINE DISCOVERY INC. [CN]/[CN]
Inventors
  • 王建非 WANG, Jianfei
  • 张杨 ZHANG, Yang
  • 孙继奎 SUN, Jikui
  • 陈曙辉 CHEN, Shuhui
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE
Priority Data
201811153373.729.09.2018CN
201910432821.522.05.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PYRAZOLOPYRIMIDINE DERIVATIVE AS SELECTIVE TRK INHIBITOR
(FR) DÉRIVÉ DE PYRAZOLOPYRIMIDINE EN TANT QU'INHIBITEUR DE TRK SÉLECTIF
(ZH) 作为选择性Trk抑制剂的吡唑并嘧啶衍生物
Abstract
(EN)
Disclosed is a compound as presented in Formula II, a tautomer thereof, and pharmaceutically acceptable salts thereof, and specifically relates to the use thereof in preparing medications for treatment of diseases related to solid tumors.
(FR)
L'invention concerne un composé tel que représenté dans la formule II, un tautomère de celui-ci, et des sels pharmaceutiquement acceptables de celui-ci, et concerne spécifiquement son utilisation dans la préparation de médicaments pour le traitement de maladies associées à des tumeurs solides.
(ZH)
本发明公开了式(Ⅱ)所示化合物、其互变异构体或其药学上可接受的盐,并涉及其在制备治疗实体瘤相关疾病的药物的应用。
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