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1. WO2020063618 - QUINOLONE DERIVATIVE HAVING INDOLEAMINE-2,3-DIOXYGENASE INHIBITED ACTIVITY

Publication Number WO/2020/063618
Publication Date 02.04.2020
International Application No. PCT/CN2019/107690
International Filing Date 25.09.2019
IPC
C07D 213/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
C07D 403/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
A61K 31/47 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61K 31/4709 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4709Non-condensed quinolines containing further heterocyclic rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61K 31/4709
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4709Non-condensed quinolines and containing further heterocyclic rings
A61K 31/4725
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
A61K 31/517
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • 深圳微芯生物科技股份有限公司 SHENZHEN CHIPSCREEN BIOSCIENCES CO., LTD. [CN]/[CN]
Inventors
  • 余金迪 YU, Jindi
  • 辛利军 XIN, Lijun
  • 山松 SHAN, Song
  • 朱江飞 ZHU, Jiangfei
  • 杨林 YANG, Lin
  • 付超 FU, Chao
  • 李志斌 LI, Zhibin
  • 鲁先平 LU, Xianping
Agents
  • 中国国际贸易促进委员会专利商标事务所 CCPIT PATENT AND TRADEMARK LAW OFFICE
Priority Data
201811128800.627.09.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) QUINOLONE DERIVATIVE HAVING INDOLEAMINE-2,3-DIOXYGENASE INHIBITED ACTIVITY
(FR) DÉRIVÉ DE QUINOLONE AYANT UNE ACTIVITÉ INHIBÉE PAR L'INDOLÉAMINE-2,3-DIOXYGÉNASE
(ZH) 具有吲哚胺-2,3-双加氧酶抑制活性的喹啉衍生物
Abstract
(EN)
Provided is a quinolone derivative having indoleamine-2,3-dioxygenase (IDO) inhibited activity. Specifically, provided are a compound of formula (I) or a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in preparation of drugs for immunoregulation and preventing and/or treating diseases related to IDO abnormal expression and/or abnormal tryptophan metabolism. Also involved are a drug combination of the quinolone derivative and an HDAC inhibitor and use thereof in preparation of antitumor drugs.
(FR)
L'invention concerne un dérivé de quinolone ayant une activité inhibée par l'indoléamine-2,3-dioxygénase (IDO). L'invention concerne spécifiquement un composé de formule (I) ou un sel pharmacologiquement acceptable de celui-ci, une composition pharmaceutique de celui-ci, un procédé de préparation de celui-ci, et son utilisation dans la préparation de médicaments pour l'immunorégulation et la prévention et/ou le traitement de maladies liées à l'expression anormale de l'IDO et/ou au métabolisme anormal du tryptophane. L'invention concerne également une combinaison de médicaments du dérivé de quinolone et d'un inhibiteur de HDAC et son utilisation dans la préparation de médicaments antitumoraux.
(ZH)
提供具有吲哚胺-2,3-双加氧酶抑制活性的喹啉衍生物,具体地,提供通式(I)化合物或其药学上可接受的盐,其药物组合物,制备方法和在制备免疫调节及预防和/或治疗与IDO表达异常和/或色氨酸代谢异常有关的疾病的药物中的用途。还涉及所述喹啉衍生物与HDAC抑制剂的联合用药及其在制备抗肿瘤药物中的用途。
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