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1. WO2020063034 - MCI DIAGNOSIS MARKER DUE TO AD AND APPLICATION THEREOF

Publication Number WO/2020/063034
Publication Date 02.04.2020
International Application No. PCT/CN2019/095667
International Filing Date 12.07.2019
IPC
C12Q 1/6883 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12N 15/113 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
CPC
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
C12Q 2600/166
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
166Oligonucleotides used as internal standards, controls or normalisation probes
C12Q 2600/178
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
178miRNA, siRNA or ncRNA
Applicants
  • 上海市精神卫生中心(上海市心理咨询培训中心) SHANGHAI MENTAL HEALTH CENTER (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENTER) [CN]/[CN]
Inventors
  • 王涛 WANG, Tao
  • 肖世富 XIAO, Shifu
  • 何海宁 HE, Haining
Agents
  • 上海智信专利代理有限公司 SHANGHAI ZHI XIN PATENT AGENT LTD.
Priority Data
201811126537.726.09.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) MCI DIAGNOSIS MARKER DUE TO AD AND APPLICATION THEREOF
(FR) MARQUEUR DE DIAGNOSTIC DE MCI DÛ À LA MA ET SON APPLICATION
(ZH) AD所致MCI诊断标志物及其应用
Abstract
(EN)
An MCI diagnosis marker due to Alzheimer's disease (AD). The marker is plasma miRNA, and the plasma miRNA comprises hsa-miR-1185-2-3p, hsa-miR-22-5p, hsa-miR-134-3p, hsa-miR-1909-3p, and hsa-miR-107. Further disclosed are an application of the marker and a corresponding kit. The present invention has beneficial effects: a biology marker having high diagnosis value for MCI due to AD is found; MCI due to AD is facilitated to be detected; and early diagnosis and early intervention of AD commonly called senile dementia are facilitated.
(FR)
La présente invention concerne un marqueur de diagnostic de MCI dû à la maladie d'Alzheimer (MA). Le marqueur est un miARN plasmatique, et le miARN plasmatique comprend les hsa-miR-1185-2-3p, hsa-miR-22-5p, hsa-miR-134-3p, hsa-miR-1909-3p, et hsa-miR-107. L'invention concerne en outre une application du marqueur et un kit correspondant. La présente invention présente des effets bénéfiques : un marqueur biologique ayant une valeur de diagnostic élevée pour le MCI dû à la MA ; un MCI dû à la MA est plus facile à détecter ; et un diagnostic précoce de la MA, communément appelée démence sénile, et une intervention précoce dans le cadre de la maladie sont facilités.
(ZH)
一种AD所致MCI诊断标志物,所述的标志物为血浆miRNA,所述的血浆miRNA包括hsa-miR-1185-2-3p、hsa-miR-22-5p、hsa-miR-134-3p、hsa-miR-1909-3p和hsa-miR-107。一种上述标志物的应用及相应的试剂盒。有益效果在于:发现了对AD所致MCI具有诊断价值的生物标志物,方便检测AD所致MCI,有利于对阿尔茨海默病俗称老年性痴呆的早期诊断和早期干预。
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