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1. WO2020062780 - MEDICAMENT FOR PREVENTING AND TREATING ISCHEMIC HEART DISEASES OR ISCHEMIC ENCEPHALOPATHY OR THROMBOSIS AND USE THEREOF

Publication Number WO/2020/062780
Publication Date 02.04.2020
International Application No. PCT/CN2019/076751
International Filing Date 01.03.2019
IPC
A61K 31/404 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 7/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
CPC
A61K 31/404
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • 百迈康生物医药科技(广州)有限公司 BMK BIOMEDICAL TECHNOLOGY (GUANGZHOU) CO., LTD. [CN]/[CN]
Inventors
  • 钟诗龙 ZHONG, Shilong
  • 马红坤 MA, Hongkun
  • 张姗姗 ZHANG, Shanshan
Agents
  • 深圳市知顶顶知识产权代理有限公司 SHENZHEN ZHIDINGDING INTELLECTUAL PROPERTY AGENCY CO., LTD.
Priority Data
201811126747.626.09.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) MEDICAMENT FOR PREVENTING AND TREATING ISCHEMIC HEART DISEASES OR ISCHEMIC ENCEPHALOPATHY OR THROMBOSIS AND USE THEREOF
(FR) MÉDICAMENT POUR LA PRÉVENTION ET LE TRAITEMENT DES MALADIES CARDIAQUES ISCHÉMIQUES OU DE L'ENCÉPHALOPATHIE ISCHÉMIQUE OU DE LA THROMBOSE ET SON UTILISATION
(ZH) 防治缺血性心脏病或缺血性脑病或血栓形成的药物及应用
Abstract
(EN)
Disclosed in the present invention are a medicament for preventing and treating ischemic heart diseases or ischemic encephalopathy or thrombosis and use thereof. The medicament comprises indole-3-methanol and a derivative thereof or diindolylmethane and a derivative thereof. The medicament further comprises a pharmaceutically acceptable carrier therefor. The carrier includes beverages or foods. The medicament can be used for treating and preventing coronary atherosclerotic heart disease, ischemic heart diseases due to luminal stenosis or occlusion caused by inflammatory thrombus, embolism or injury, thrombosis, cerebral infarction, ischemic cerebral apoplexy, cerebral thrombus, cerebral embolism, lacunar ischemic cerebral apoplexy, multiple ischemic cerebral apoplexy and transient ischemic attack.
(FR)
La présente invention concerne un médicament pour la prévention et le traitement des maladies cardiaques ischémiques ou de l'encéphalopathie ischémique ou de la thrombose et son utilisation. Le médicament comprend de l'indole-3-méthanol et un dérivé de celui-ci ou du diindolylméthane et un dérivé de celui-ci. Le médicament comprend en outre un support de qualité pharmaceutique. Le support comprend des boissons ou des aliments. Le médicament peut être utilisé pour traiter et prévenir une athérosclérose coronarienne, des maladies cardiaques ischémiques dues à une sténose ou à une occlusion luminale provoquée par un thrombus inflammatoire, une embolie ou une lésion, la thrombose, l'infarctus cérébral, l'apoplexie cérébrale ischémique, un thrombus cérébral, l'embolie cérébrale, l'infarctus cérébral lacunaire, l'infarctus cérébral multiple et l'attaque ischémique transitoire.
(ZH)
本发明公开了防治缺血性心脏病或缺血性脑病或血栓形成的药物及应用,所述药物包含吲哚-3-甲醇及其衍生物,或二吲哚甲烷及其衍生物;所述药物还包括其药学上可接受的载体,所述载体包括饮料或食物;所述药物可用于治疗和预防冠状动脉粥样硬化性心脏病,因炎症血栓、栓塞或损伤导致管腔狭窄或闭塞而引起的缺血心脏病,血栓形成、以及脑梗,缺血性脑中风,脑血栓,脑栓塞,腔隙性缺血性脑中风,多发性缺血性脑中风及小中风。
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