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1. WO2020062445 - PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING NITM AND PHARMACEUTICAL USE THEREOF

Publication Number WO/2020/062445
Publication Date 02.04.2020
International Application No. PCT/CN2018/113969
International Filing Date 05.11.2018
IPC
A61K 31/46 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
468-Azabicyclo octane; Derivatives thereof, e.g. atropine, cocaine
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 47/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 47/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
04Non-metals; Compounds thereof
A61K 47/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
CPC
A61K 31/46
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
A61K 47/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 47/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
A61P 27/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
10for accommodation disorders, e.g. myopia
Applicants
  • 沈阳兴齐眼药股份有限公司 SHENYANG XINGQI PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 刘继东 LIU, Jidong
  • 王宁利 WANG, Ningli
  • 郭雷 GUO, Lei
  • 杨强 YANG, Qiang
  • 高坤 GAO, Kun
  • 李林蔚 LI, Linwei
  • 顾红 GU, Hong
  • 孙洋 SUN, Yang
  • 付乐 FU, Le
Agents
  • 中国国际贸易促进委员会专利商标事务所 CCPIT PATENT AND TRADEMARK LAW OFFICE
Priority Data
201811119899.325.09.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING NITM AND PHARMACEUTICAL USE THEREOF
(FR) COMPOSITION PHARMACEUTIQUE POUR PRÉVENIR ET TRAITER LA NITM ET UTILISATION PHARMACEUTIQUE ASSOCIÉE
(ZH) 防治NITM的药物组合物及其医药用途
Abstract
(EN)
The present invention belongs to the pharmaceutical field, and relates to a pharmaceutical composition for preventing and treating NITM and a pharmaceutical use thereof. Specifically, the pharmaceutical composition is an ophthalmic pharmaceutical composition, such as an ophthalmic formulation. Specifically, the present invention relates to a pharmaceutical composition comprising 0.001% - 0.2% of atropine or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable adjuvants. The pH value of the pharmaceutical composition is 4.0 - 6.5. The pharmaceutical composition comprises 0.5% - 5% of a pH adjusting agent selected from any one or more of sodium dihydrogen phosphate, disodium hydrogen phosphate, citric acid, citrates, boric acid and borates. The pharmaceutical compositions of the present invention are capable of treating and/or preventing NITM effectively, having good application prospects.
(FR)
La présente invention concerne le domaine pharmaceutique, et concerne une composition pharmaceutique pour la prévention et le traitement de la NITM et une utilisation pharmaceutique de celle-ci. Spécifiquement, la composition pharmaceutique est une composition pharmaceutique ophtalmique, telle qu'une formulation ophtalmique. Spécifiquement, la présente invention concerne une composition pharmaceutique comprenant de 0,001% à 0,2% d'atropine ou d'un sel pharmaceutiquement acceptable de celle-ci et un ou plusieurs excipients pharmaceutiquement acceptables. La valeur de pH de la composition pharmaceutique est de 4,0 à 6,5. La composition pharmaceutique comprend de 0,5 % à 5 % d'un agent d'ajustement du pH choisi parmi un ou plusieurs parmi le dihydrogénophosphate de sodium, le phosphate d'hydrogène disodique, l'acide citrique, les citrates, l'acide borique et les borates. Les compositions pharmaceutiques de la présente invention sont capables de traiter et/ou de prévenir efficacement la NITM, ayant de bonnes perspectives d'application.
(ZH)
本发明属于医药领域,涉及一种防治NITM的药物组合物及其医药用途。具体地,所述药物组合物为眼用药物组合物例如眼用制剂。具体地,本发明涉及一种药物组合物,其包含0.001%-0.2%的阿托品或其可药用盐,以及一种或多种药学上可接受的辅料;其中,所述药物组合物的pH值为4.0-6.5;所述药物组合物包含0.5%-5%的pH调节剂,所述pH调节剂选自磷酸二氢钠、磷酸氢二钠、枸橼酸、枸橼酸盐、硼酸和硼酸盐中的任意一种或多种。本发明的药物组合物能够有效地治疗和/或预防NITM,具有良好的应用前景。
Also published as
Latest bibliographic data on file with the International Bureau