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1. WO2020061809 - APPLICATIONS OF 1,2,3,6,7-PENTAMETHOXYBENZOPHENONE IN PREPARING MEDICAMENT FOR PREVENTING AND TREATING HIPPOCAMPAL NEURON-RELATED DISEASES

Publication Number WO/2020/061809
Publication Date 02.04.2020
International Application No. PCT/CN2018/107598
International Filing Date 26.09.2018
IPC
A61K 31/352 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61P 25/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 25/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
CPC
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • 泰州丹鼎生物科技有限公司 TAIZHOU DANDING BIOTECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 顾正兵 GU, Zhengbing
  • 梁延春 LIANG, Yanchun
  • 陶月红 TAO, Yuehong
  • 刘艳芳 LIU, Yanfang
  • 曾铖 ZENG, Cheng
Agents
  • 北京联瑞联丰知识产权代理事务所(普通合伙) BEIJING UTC LIANFENG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP)
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) APPLICATIONS OF 1,2,3,6,7-PENTAMETHOXYBENZOPHENONE IN PREPARING MEDICAMENT FOR PREVENTING AND TREATING HIPPOCAMPAL NEURON-RELATED DISEASES
(FR) APPLICATIONS DE 1,2,3,6,7-PENTAMÉTHOXYBENZOPHÉNONE DANS LA PRÉPARATION D'UN MÉDICAMENT DESTINÉ À LA PRÉVENTION ET AU TRAITEMENT DE MALADIES LIÉES AUX NEURONES DE L'HIPPOCAMPE
(ZH) 一种1,2,3,6,7-五甲氧基二苯吡酮在制备防治海马神经元相关疾病药物的应用
Abstract
(EN)
Disclosed are applications of a 1,2,3,6,7-pentamethoxybenzophenone in preparing a medicament for preventing and treating diseases having pathological features caused by hippocampal neuron damage or apoptosis, the chemical structural formula of the 1,2,3,6,7-pentamethoxybenzophenone is as represented by formula I. Experiments show that 1,2,3,6,7-pentamethoxybenzophenone promotes hippocampal neuron regeneration, increases the expression of hippocampal neuron apoptosis-related protein Bcl-2, reduces the expression of hippocampal neuron apoptosis-related proteins Bax and Caspase-8, and inhibits hippocampal neuron apoptosis. This is applicable in preventing and treating diseases having pathological features caused by hippocampal neuron damage or apoptosis, and provides an experimental basis for clinical prevention and treatment of diseases such as depression, Alzheimer's disease, anxiety, and Parkinson's disease.
(FR)
L'invention concerne des applications d'une 1,2,3,6,7-pentaméthoxybenzophénone dans la préparation d'un médicament destiné à la prévention et au traitement de maladies présentant des caractéristiques pathologiques provoquées par une lésion ou une apoptose des neurones de l'hippocampe, la formule chimique développée de la 1,2,3,6,7-pentaméthoxybenzophénone est telle que représentée par la formule I. Des expériences montrent que la 1,2,3,6,7-pentaméthoxybenzophénone favorise la régénération des neurones de l'hippocampe, augmente l'expression de la protéine Bcl-2 liée à l'apoptose des neurones de l'hippocampe, réduit l'expression des protéines Bax et Caspase-8 liées à l'apoptose des neurones de l'hippocampe, et inhibe l'apoptose des neurones de l'hippocampe. Ceci est applicable dans la prévention et le traitement de maladies présentant des caractéristiques pathologiques provoquées par une lésion ou une apoptose des neurones de l'hippocampe, et fournit une base expérimentale en vue de la prévention et du traitement cliniques de maladies telles que la dépression, la maladie d'Alzheimer, l'anxiété et la maladie de Parkinson.
(ZH)
本发明公开了一种1,2,3,6,7-五甲氧基二苯吡酮在制备预防和治疗海马神经元损伤或凋亡导致的病理学特征疾病的药物中的应用,所述1,2,3,6,7-五甲氧基二苯吡酮的化学结构式如式I所示。实验表明,1,2,3,6,7-五甲氧基二苯吡酮可以促进海马神经元再长,增加海马神经元凋亡相关蛋白Bcl-2的表达,降低海马神经元凋亡相关蛋白Bax与Caspase-8的表达,抑制海马神经元凋亡。可用于预防和治疗由海马神经元损伤导致的病理学特征疾病,为临床预防和治疗抑郁症、阿尔茨海默症、焦虑症和帕金森症等疾病提供实验依据。
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