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1. WO2020061688 - MODULATION OF GRANZYME K ACTIVITY IN THE TREATMENT OF SKIN CONDITIONS

Publication Number WO/2020/061688
Publication Date 02.04.2020
International Application No. PCT/CA2019/051359
International Filing Date 24.09.2019
IPC
A61K 38/57 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
57from animals; from humans
A61K 31/7088 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
CPC
A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 38/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
57from animals; from humans
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
Applicants
  • THE UNIVERSITY OF BRITISH COLUMBIA [CA]/[CA]
Inventors
  • GRANVILLE, David J.
  • TURNER, Christopher
  • ZEGLINSKI, Matthew
  • RICHARDSON, Katlyn
  • HIROYASU, Sho
Agents
  • C6 PATENT GROUP INCORPORATED
Priority Data
62/735,41424.09.2018US
62/851,79023.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MODULATION OF GRANZYME K ACTIVITY IN THE TREATMENT OF SKIN CONDITIONS
(FR) MODULATION DE L'ACTIVITÉ DU GRANZYME K DANS LE TRAITEMENT D'AFFECTIONS CUTANÉES
Abstract
(EN)
In one aspect, methods for treating inflammatory skin conditions, such as atopic dermatitis and psoriasis, are provided. In another aspect, methods for promoting skin wound healing are provided. In a further aspect, methods for treating skin wounds, such as thermal and pressure injury are provided. In the methods, the activity of Granzyme K is reduced.
(FR)
Dans un aspect, l'invention concerne des procédés de traitement d'affections cutanées inflammatoires, telles que la dermatite atopique et le psoriasis. Dans un autre aspect, l'invention concerne des procédés pour favoriser la cicatrisation d'une plaie cutanée. Dans un autre aspect, l'invention concerne des procédés de traitement de plaies cutanées, telles que des lésions thermiques et de pression. Dans les procédés, l'activité de granzyme K est réduite.
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