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1. WO2020061377 - SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF

Publication Number WO/2020/061377
Publication Date 26.03.2020
International Application No. PCT/US2019/052023
International Filing Date 19.09.2019
IPC
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • GENENTECH, INC. [US]/[US] (US)
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AllExceptUS)
Inventors
  • MALHOTRA, Sushant
  • STIVALA, Craig
  • WEI, BinQing
  • CHAN, Bryan K.
  • HEFFRON, Timothy
  • LAINCHBURY, Michael
  • MADIN, Andrew
  • PANCHAL, Terry Aaron
  • SEWARD, Eileen Mary
  • BLENCH, Toby
  • CARTWRIGHT, Matthew W.
  • DECHAUX, Elsa Amandine
  • ELLIOTT, Richard
  • GANCIA, Emanuela
Agents
  • TIAN, Zongqiang Bill
  • AUMAIS, Jonathan
  • BONE, Richard G.A.
  • BUCKWALTER, Brian L.
  • CHANG, Y. Elaine
  • CHI, I. Shannon
  • CLARK, Kevin M.
  • COBURN, Cara M.
  • COLANTONIO, Jessica R.
  • CRISSEY, Todd M.
  • CUI, Steven
  • DAVIS, Bradley E.
  • DAVIS, Jennifer L.
  • DREGER, Ginger
  • FANG, Carol A.
  • GHOSE, Shameek
  • HALL, Robert C.
  • HARLOCKER, Susan
  • HEIDER, Julie A.
  • HESSLER, Amy
  • HILL, Laurie L.
  • JOHNSTON, Sean A.
  • KAFKA, Mark D.
  • KAIS, Samuel
  • KALINOWSKI, Grant E.
  • KRAMMER, Andre
  • LEE, Michelle
  • LEE, Wendy M.
  • LI, Qianru
  • MACKENZIE, Katherine J.
  • MCCLELLAN, Kelly B.
  • REDDY, Daphne
  • ROPP, Traci H.
  • SCHWARTZ, Timothy R.
  • SCOTT, Derek B.
  • SHERMAN, Daniel E.
  • SCHOLZ, Charles K.
  • SHU, Cindy
  • TAN, Anna M.
  • WAIS, Rebecca J.
  • WHITEHEAD, Andrew P.
  • WONG, Charles C.
Priority Data
PCT/CN2018/10653619.09.2018CN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS 2,3-DIHYDRO-7-AZAINDOLE SPIROCYCLIQUES ET LEURS UTILISATIONS
Abstract
(EN) Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I), variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.
(FR) L'invention concerne des composés 2,3-dihydro-7-azaindole spirocycliques de formule (I), leurs variantes et leur utilisation en tant qu'inhibiteurs de HPK1 (kinase hématopoïétique 1). Les composés sont utiles dans le traitement de troubles dépendant de HPK1 et l'amélioration d'une réponse immunitaire. L'invention concerne également des procédés d'inhibition de HPK1, des procédés de traitement de troubles dépendant de HPK1, des procédés d'amélioration d'une réponse immunitaire, et des procédés de préparation des composés 2,3-dihydro-7-azaindole spirocycliques.
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