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1. WO2020061286 - OCTREOTIDE MICROSPHERE-BASED ARTERIAL EMBOLIZATION FOR TREATING OBESITY

Publication Number WO/2020/061286
Publication Date 26.03.2020
International Application No. PCT/US2019/051890
International Filing Date 19.09.2019
IPC
A61K 38/08 2019.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
C07K 7/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
A61K 9/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
Applicants
  • BIOVENA SCIENCE, LLC; C/O CastleRock Management 489 Fifth Avenue, Floor 33 New York, New York 10017, US
Inventors
  • NURILI, Fuad; US
  • ARAS, Omer; US
Agents
  • MORRISON, Alan J.; US
Priority Data
62/733,70420.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OCTREOTIDE MICROSPHERE-BASED ARTERIAL EMBOLIZATION FOR TREATING OBESITY
(FR) EMBOLISATION ARTÉRIELLE BASÉE SUR DES MICROSPHÈRES D'OCTRÉOTIDE POUR TRAITER L'OBÉSITÉ
Abstract
(EN)
This invention provides a method for causing weight loss in a subject comprising introducing biodegradable microspheres into one or more of the subject's gastric arteries, wherein the microspheres (i) have a d90 value from 40 μm to 500 μm; (ii) comprise polylactic acid (PLA) and/or polylactic co-glycolic acid (PLGA); (iii) carry a therapeutically effective amount of pharmaceutical octreotide; (iv) embolize gastric arterial vessels supplied by the one or more arteries into which they are introduced; and (v) release octreotide during embolization.
(FR)
La présente invention concerne un procédé pour provoquer une perte de poids chez un sujet, comprenant l'introduction de microsphères biodégradables dans une ou plusieurs des artères gastriques du sujet, les microsphères (i) ayant une valeur d90 de 40 µm à 500 µm ; (ii) comprenant de l'acide polylactique (PLA) et/ou de l'acide polylactique co-glycolique (PLGA) ; (iii) transportant une quantité thérapeutiquement efficace d'octréotide pharmaceutique ; (iv) embolisant les vaisseaux artériels gastriques fournis par la ou les artères dans lesquelles elles sont introduites ; et (v) libérant l'octréotide pendant l'embolisation.
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