Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020056145 - ANTI-HIV ANTIBODY 10-1074 VARIANTS

Publication Number WO/2020/056145
Publication Date 19.03.2020
International Application No. PCT/US2019/050823
International Filing Date 12.09.2019
IPC
A61K 39/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
C07K 16/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
C12P 21/08 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
08Monoclonal antibodies
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/507
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
507Comprising a combination of two or more separate antibodies
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
C07K 16/1045
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
1036Retroviridae, e.g. leukemia viruses
1045Lentiviridae, e.g. HIV, FIV, SIV
C07K 2317/55
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
55Fab or Fab'
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applicants
  • THE ROCKEFELLER UNIVERSITY [US]/[US]
Inventors
  • NUSSENZWEIG, Michel
  • KETCHEM, Randal, R.
  • SISKA, Christine, C.
  • GILLESPIE, Alison, J.
  • CLARK, Rutilio, H.
  • KERWIN, Bruce, A.
Agents
  • NORTON, Gerard, P.
  • BARRISON, Flynn
  • BUTCH III, Peter, J.
  • CHEN, Joe
  • HALPERN, Nancy, E.
Priority Data
62/731,35614.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-HIV ANTIBODY 10-1074 VARIANTS
(FR) VARIANTS D'ANTICORPS ANTI-VIH 10-1074
Abstract
(EN)
The present disclosure provides optimized broadly-neutralizing anti-HIV antibodies, having modified light chain variable regions and/or heavy chain variable regions leading to improved biophysical characteristics. The present disclosure also provides methods for producing these anti-HIV antibodies and methods of use thereof.
(FR)
La présente invention concerne des anticorps anti-VIH largement neutralisants optimisés, ayant des régions variables de chaîne légère modifiées et/ou des régions variables de chaîne lourde conduisant à des caractéristiques biophysiques améliorées. La présente invention concerne également des procédés de fabrication et des méthodes d'utilisation de ces anticorps anti-VIH.
Latest bibliographic data on file with the International Bureau