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1. WO2020040210 - BIOMARKER FOR MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (ME/CFS)

Publication Number WO/2020/040210
Publication Date 27.02.2020
International Application No. PCT/JP2019/032673
International Filing Date 21.08.2019
IPC
C12Q 1/6809 2018.01
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
Applicants
  • 国立研究開発法人国立精神・神経医療研究センター NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY [JP]/[JP]
  • Repertoire Genesis株式会社 REPERTOIRE GENESIS INCORPORATION [JP]/[JP]
Inventors
  • 山村 隆 YAMAMURA Takashi
  • 佐藤 和貴郎 SATO Wakiro
  • 小野 紘彦 ONO Hirohiko
  • 松谷 隆治 MATSUTANI Takaji
  • 中村 征史 NAKAMURA Yukio
  • 北浦 一孝 KITAURA Kazutaka
Agents
  • 山本 秀策 YAMAMOTO Shusaku
  • 森下 夏樹 MORISHITA Natsuki
  • ▲駒▼谷 剛志 KOMATANI Takeshi
  • 飯田 貴敏 IIDA Takatoshi
  • 石川 大輔 ISHIKAWA Daisuke
  • 山本 健策 YAMAMOTO Kensaku
Priority Data
2018-15538022.08.2018JP
2019-04488512.03.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) BIOMARKER FOR MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (ME/CFS)
(FR) BIOMARQUEUR DE L'ENCÉPHALOMYÉLITE MYALGIQUE/DU SYNDROME DE FATIGUE CHRONIQUE (EM/SFC)
(JA) 筋痛性脳脊髄炎/慢性疲労症候群(ME/CFS)のバイオマーカー
Abstract
(EN)
A method for diagnosing myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is provided in the present disclosure. The present disclosure provides a method that uses the B cell receptor (BCR) repertoire as an indicator of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). One or more variables selected from the group consisting of the frequency of use of one or more genes in the IgGH heavy chain variable region of the BCR in a subject, the BCR diversity index in a subject, and the level of one or more immune cell subpopulations in a subject can be used as an indicator of ME/CFS in the subject.
(FR)
La présente invention concerne une méthode de diagnostic de l'encéphalomyélite myalgique/du syndrome de fatigue chronique (EM/SFC). La présente invention concerne une méthode qui utilise le répertoire du récepteur des lymphocytes B (BCR) comme un indicateur de l'encéphalomyélite myalgique/du syndrome de fatigue chronique (EM/SFC). Une ou plusieurs variables sélectionnées dans le groupe constitué par la fréquence d'utilisation d'un ou plusieurs gènes de la région variable de chaîne lourde IgGH du BCR chez un sujet, l'indice de diversité du BCR chez un sujet, et le niveau d'une ou plusieurs sous-populations de cellules immunitaires chez un sujet peuvent être utilisées comme un indicateur de EM/SFC chez le sujet.
(JA)
本開示において、筋痛性脳脊髄炎/慢性疲労症候群(ME/CFS)の診断を行う方法が提供される。本開示は、B細胞受容体(BCR)レパトアを筋痛性脳脊髄炎/慢性疲労症候群(ME/CFS)の指標とする方法を提供する。対象におけるBCRのIgGH鎖可変領域における1つ以上の遺伝子の使用頻度、対象におけるBCR多様性指数、および対象における1つ以上の免疫細胞亜集団量からなる群から選択される1つまたは複数の変数を、対象におけるME/CFSの指標として用いることができる。
Also published as
JP2020538443
EP2019853005
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