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1. WO2020033731 - POLYPEPTIDE INTEGRIN ANTAGONISTS

Publication Number WO/2020/033731
Publication Date 13.02.2020
International Application No. PCT/US2019/045762
International Filing Date 08.08.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
78
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
64
Cyclic peptides containing only normal peptide links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
C07K 14/78 (2006.01)
C07K 14/705 (2006.01)
C07K 7/64 (2006.01)
A61P 1/16 (2006.01)
A61K 49/00 (2006.01)
Applicants
  • THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, Massachusetts 02114, US
  • ARNAOUT, M. Amin [US/US]; US
Inventors
  • ARNAOUT, M. Amin; US
Agents
  • DAVEY, Evan, A.; US
  • FOLLETT, PH.D., Angela D.; US
Priority Data
62/715,86008.08.2018US
62/757,12607.11.2018US
62/786,80431.12.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYPEPTIDE INTEGRIN ANTAGONISTS
(FR) ANTAGONISTES DE L'INTÉGRINE POLYPEPTIDIQUE
Abstract
(EN)
The present application relates to polypeptides which are integrin antagonists. Methods of preparing the integrin antagonists and methods of treating diseases and disorders associated with abnormal levels and/or expression of one or more integrins are also provided.
(FR)
La présente invention concerne des polypeptides qui sont des antagonistes de l'intégrine. L'invention concerne également des procédés de préparation des antagonistes de l'intégrine et des procédés de traitement de maladies et de troubles associés à des niveaux et/ou une expression anormaux d'une ou de plusieurs intégrines.
Latest bibliographic data on file with the International Bureau