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1. WO2020023560 - ISOQUINOLINE COMPOUNDS AND USES THEREOF

Publication Number WO/2020/023560
Publication Date 30.01.2020
International Application No. PCT/US2019/043123
International Filing Date 23.07.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
515
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/241
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
551
having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
554
having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
501
not condensed and containing further heterocyclic rings
A61P 35/00 (2006.01)
C07D 401/12 (2006.01)
C07D 401/14 (2006.01)
C07D 403/12 (2006.01)
C07D 403/14 (2006.01)
C07D 405/14 (2006.01)
CPC
A61P 35/00
C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
C07D 405/14
Applicants
  • F. HOFFMANN-LA ROCHE AG; -- (AllExceptUS)
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (US)
Inventors
  • LIANG, Jun; US
  • MALHOTRA, Sushant; US
  • MENDONCA, Rohan V.; US
  • RAJAPAKSA, Naomi; US
  • SIU, Michael; US
  • STIVALA, Craig; US
  • TELLIS, John C.; US
  • WEI, BinQing; US
  • CHAN, Bryan K.; US
  • DROBNICK, Joy Alison; US
  • GAZZARD, Lewis J.; US
  • HEFFRON, Timothy; US
  • JONES, Graham; GB
  • LAINCHBURY, Michael; GB
  • MADIN, Andrew; GB
  • SEWARD, Eileen; GB
  • CARTWRIGHT, Matthew W.; GB
  • GANCIA, Emanuela; GB
  • FAVOR, David; CN
  • FONG, Kin-Chiu; CN
  • GOOD, Andrew; CN
  • HU, Yonghan; CN
Agents
  • TIAN, Zongqiang Bill; US
  • AUMAIS, Jonathan; US
  • BONE, Richard G.A.; US
  • BUCKWALTER, Brian L.; US
  • CHANG, Y. Elaine; US
  • CHI, I. Shannon; US
  • CLARK, Kevin M.; US
  • COBURN, Cara M.; US
  • COLANTONIO, Jessica R.; US
  • CRISSEY, Todd M.; US
  • CUI, Steven; US
  • DAVIS, Bradley E.; US
  • DAVIS, Jennifer L.; US
  • DREGER, Ginger; US
  • FANG, Carol A.; US
  • GHOSE, Shameek; US
  • HALL, Robert C.; US
  • HARLOCKER, Susan; US
  • HEIDER, Julie A.; US
  • HESSLER, Amy; US
  • HILL, Laurie L.; US
  • JOHNSTON, Sean A.; US
  • KAFKA, Mark D.; US
  • KAIS, Samuel; US
  • KALINOWSKI, Grant E.; US
  • KRAMMER, Andre; US
  • LEE, Michelle; US
  • LEE, Wendy M.; US
  • LI, Qianru; US
  • MACKENZIE, Katherine J.; US
  • MCCLELLAN, Kelly B.; US
  • REDDY, Daphne; US
  • ROPP, Traci H.; US
  • SCHWARTZ, Timothy R.; US
  • SCOTT, Derek B.; US
  • SHERMAN, Daniel E.; US
  • SCHOLTZ, Charles K.; US
  • SHU, Cindy; US
  • TAN, Anna M.; US
  • WAIS, Rebecca J.; US
  • WHITEHEAD, Andrew P.; US
  • WONG, Charles C.; US
Priority Data
PCT/CN2018/09678024.07.2018CN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ISOQUINOLINE COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS D'ISOQUINOLINE ET LEURS UTILISATIONS
Abstract
(EN)
Isoquinoline compounds of formula (I) variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
(FR)
L'invention concerne des composés d'isoquinoléine de formule (I) et leur utilisation en tant qu'inhibiteurs de HPK1 (kinase hématopoïétique 1). Les composés de l'invention sont utiles dans le traitement de troubles dépendant de HPK1 et pour l'amélioration d'une réponse immunitaire. L'invention concerne également des procédés d'inhibition de HPK1, des méthodes de traitement de troubles dépendant de HPK1, des procédés d'amélioration d'une réponse immunitaire, et des procédés de préparation des composés d'isoquinoline.
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