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1. WO2020016129 - TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS

Publication Number WO/2020/016129
Publication Date 23.01.2020
International Application No. PCT/EP2019/068832
International Filing Date 12.07.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
C07D 471/04 (2006.01)
C07D 487/04 (2006.01)
A61P 11/06 (2006.01)
A61K 31/519 (2006.01)
CPC
A61P 11/06
C07D 471/04
C07D 487/04
Applicants
  • CHIESI FARMACEUTICI S.P.A. [IT/IT]; Via Palermo, 26/A 43122 PARMA, IT
Inventors
  • ACCETTA, Alessandro; IT
  • RANCATI, Fabio; IT
  • CAPELLI, Anna Maria; IT
  • CLARK, David Edward; IT
  • TISSELLI, Patrizia; IT
  • EDWARDS, Christine; IT
  • CHEGUILLAUME, Arnaud Jean Francois Auguste; IT
  • BHALAY, Gurdip; IT
Agents
  • MINOJA, Fabrizio; IT
Priority Data
18183733.716.07.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS
(FR) DÉRIVÉS DE TYROSINE AMIDE UTILISÉS EN TANT QU'INHIBITEURS DE LA RHO-KINASE
Abstract
(EN)
The invention relates to compounds of formula I inhibiting Rho Kinase that are bicyclic dihydropyrimidine-carboxamide derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
(FR)
L'invention concerne des composés de formule I inhibant la Rho Kinase qui sont des dérivés de dihydropyrimidine-carboxamide bicycliques, des procédés de préparation de tels composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. Plus particulièrement, les composés selon l'invention peuvent être utiles dans le traitement de nombreux troubles associés à des mécanismes enzymatiques ROCK, telles que des maladies pulmonaires y compris l'asthme, la bronchopneumopathie chronique obstructive (BPCO), la fibrose pulmonaire idiopathique (IPF) et l'hypertension artérielle pulmonaire (HTAP).
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