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1. WO2020010090 - NOVEL IMMUNODULATING SMALL MOLECULES

Publication Number WO/2020/010090
Publication Date 09.01.2020
International Application No. PCT/US2019/040313
International Filing Date 02.07.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70
condensed with carbocyclic rings or ring systems
72
Quinazolines; Hydrogenated quinazolines
86
with hetero atoms directly attached in position 4
94
Nitrogen atoms
A61K 39/39 (2006.01)
C07D 239/94 (2006.01)
CPC
A61K 31/702
A61K 31/7034
A61K 31/7036
A61K 31/7048
A61K 31/7056
A61K 9/0043
Applicants
  • AYUVIS RESEARCH, INC. [US/US]; 1120 South Freeway, Suite 123E Fort Worth, TX 76104, US
Inventors
  • ACHARYA, Suchismita; US
  • DAS, Pragnya; US
  • AGARWAL, Beamon; US
Agents
  • FLORES, Edwin, S.; US
  • CHALKER FLORES, LLP; 14951 North Dallas Parkway, Suite 400 Dallas, TN 75254, US
Priority Data
16/460,21102.07.2019US
62/693,02302.07.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL IMMUNODULATING SMALL MOLECULES
(FR) NOUVELLES PETITES MOLÉCULES IMMUNOMODULATRICES
Abstract
(EN)
The present invention includes novel compositions and methods for treating comprising a compound with the Formula I: where n = 0-5; X = NH, O, S, CH2; Y = Phenyl, a phenyl group substituted with at least one methyl, a phenyl group substituted with at least one nitro, a phenyl group substituted with at least one nitrogen, a phenyl group substituted with at least one boron, aryl, substituted aryl, heteroaryl, four to six membered cycloalkyl, four to six membered heterocycloalkyl; R = H, C(O)R2, SO2R2; R1 = H, C(O)R2, SO2R2; R2 = Ethyl, methyl, isopropyl, n-propyl, t-butyl, n- butyl, NH2, NR3R4; R3, R4 = Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, three to six membered cycloalkyl and Z = NH, O, S, CH2 or none, wherein the amount of the compound is selected to either inhibit or activate the immune response.
(FR)
La présente invention concerne de nouvelles compositions et de nouveaux procédés de traitement comprenant un composé de formule I : dans laquelle n = 0-5; X = NH, O, S, CH2; Y = phényle, un groupe phényle substitué par au moins un méthyle, un groupe phényle substitué par au moins un nitro, un groupe phényle substitué par au moins un atome d'azote, un groupe phényle substitué par au moins un atome de bore, un aryle, un aryle substitué, un hétéroaryle, un cycloalkyle de quatre à six chaînons, un hétérocycloalkyle de quatre à six chaînons; R = H, C(O)R2, SO2R2; R1 = H, C(O)R2, SO2R2; R2 = éthyle, méthyle, isopropyle, n-propyle, t-butyle, n-butyle, NH2, NR3R4; R3, R4 = éthyle, méthyle, isopropyle, n-propyle, t-butyle, n-butyle, un cycloalkyle de trois à six chaînons et Z = NH, O, S, CH2 ou aucun, la quantité du composé étant sélectionnée pour inhiber ou activer la réponse immunitaire.
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