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1. WO2020009175 - METHOD FOR INSPECTING FOR TANKYRASE INHIBITOR SENSITIVITY, PHARMACEUTICAL COMPOSITION ENHANCING EFFECT THEREOF, AND PHARMACEUTICAL SCREENING METHOD

Publication Number WO/2020/009175
Publication Date 09.01.2020
International Application No. PCT/JP2019/026552
International Filing Date 04.07.2019
IPC
[IPC code unknown for C12Q 1/6827]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
[IPC code unknown for C12Q 1/6851]
[IPC code unknown for C12Q 1/686]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12Q 1/6827 (2018.01)
A61K 31/7088 (2006.01)
A61K 31/713 (2006.01)
A61K 45/00 (2006.01)
A61K 48/00 (2006.01)
A61P 35/00 (2006.01)
CPC
A61K 31/7088
A61K 31/713
A61K 45/00
A61K 48/00
A61P 35/00
A61P 43/00
Applicants
  • 公益財団法人がん研究会 JAPANESE FOUNDATION FOR CANCER RESEARCH [JP/JP]; 東京都江東区有明三丁目8番31号 8-31, Ariake 3-chome, Koto-ku, Tokyo 1358550, JP
Inventors
  • 清宮 啓之 SEIMIYA Hiroyuki; JP
  • 藤原 千明 FUJIWARA Chiaki; JP
  • 杉本 芳一 SUGIMOTO Yoshikazu; JP
Agents
  • 白形 由美子 SHIRAKATA Yumiko; JP
Priority Data
2018-12947106.07.2018JP
2019-03258826.02.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR INSPECTING FOR TANKYRASE INHIBITOR SENSITIVITY, PHARMACEUTICAL COMPOSITION ENHANCING EFFECT THEREOF, AND PHARMACEUTICAL SCREENING METHOD
(FR) PROCÉDÉ D'INSPECTION DE LA SENSIBILITÉ À DES INHIBITEURS DE TANKYRASE, COMPOSITION PHARMACEUTIQUE AMÉLIORANT L'EFFET DE CES DERNIERS, ET PROCÉDÉ DE CRIBLAGE PHARMACEUTIQUE
(JA) タンキラーゼ阻害剤感受性を検査する方法、その効果を増強する医薬組成物、及び医薬のスクリーニング方法
Abstract
(EN)
As a result of searching for a synthetic lethal factor whereby sensitivity to tankyrase inhibitors could be increased and the effect thereof enhanced, a discovery was made that TMED10 functions as a synthetic lethal factor for tankyrase inhibitors. A novel anticancer agent is provided that is capable of increasing sensitivity to tankyrase inhibitors and suppressing cell growth, as a result of suppressing TMED10 expression or inhibiting vesicular transport which is a function thereof.
(FR)
À la suite de la recherche d'un facteur létal synthétique permettant à la sensibilité à des inhibiteurs de tankyrase d'être augmentée et à l'effet de ces derniers d'être amélioré, il a été découvert que TMED10 fonctionne comme un facteur létal synthétique pour des inhibiteurs de tankyrase. L'invention concerne un nouvel agent anticancéreux qui est apte à augmenter la sensibilité à des inhibiteurs de tankyrase et à supprimer la croissance cellulaire, en conséquence de la suppression de l'expression de TMED10 ou de l'inhibition du transport vésiculaire qui est une fonction de ce dernier.
(JA)
タンキラーゼ阻害剤に対する感受性を高め、その効果を増強することができる合成致死因子の探索を行った。その結果、TMED10がタンキラーゼ阻害剤の合成致死因子として機能することを見出した。TMED10の発現を抑制すること、あるいはその機能である小胞輸送を阻害することによって、タンキラーゼ阻害剤に対する感受性を高め、細胞増殖を抑制することができる。新しいコンセプトの抗がん剤を提供することができる。
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