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1. WO2020009132 - METHOD FOR PRODUCING DIARYLPYRIDINE DERIVATIVES

Publication Number WO/2020/009132
Publication Date 09.01.2020
International Application No. PCT/JP2019/026395
International Filing Date 03.07.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
319
Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
10
1,4-Dioxanes; Hydrogenated 1,4-dioxanes
12
not condensed with other rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61
Other general methods
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
444
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C07D 319/12 (2006.01)
C07B 61/00 (2006.01)
C07D 405/12 (2006.01)
C07D 405/14 (2006.01)
A61K 31/444 (2006.01)
A61P 35/00 (2006.01)
CPC
A61K 31/444
A61P 35/00
C07B 61/00
C07D 319/12
C07D 405/12
C07D 405/14
Applicants
  • 第一三共株式会社 DAIICHI SANKYO COMPANY, LIMITED [JP/JP]; 東京都中央区日本橋本町三丁目5番1号 3-5-1, Nihonbashi Honcho, Chuo-ku, Tokyo 1038426, JP
Inventors
  • 安藝 祐一 AKI Yuichi; JP
  • 鳥山 史彦 TORIYAMA Fumihiko; JP
  • 桜井 なつ樹 SAKURAI Natsuki; JP
  • 亀田 藍 KAMEDA Ai; JP
  • 小倉 友和 OGURA Tomokazu; JP
Agents
  • 石橋 公樹 ISHIBASHI Koki; JP
  • 竹元 利泰 TAKEMOTO Toshiyasu; JP
Priority Data
2018-12719704.07.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR PRODUCING DIARYLPYRIDINE DERIVATIVES
(FR) PROCÉDÉ DE PRODUCTION DE DÉRIVÉS DE DIARYLPYRIDINE
(JA) ジアリールピリジン誘導体の製造方法
Abstract
(EN)
The present invention pertains to a novel method for producing diarylpyridine derivatives, the purpose of the present invention being to provide a industrially useful, novel method. A novel method for synthesizing pyridine rings without using palladium, a strong base, or reaction under high temperature was developed. In particular, success was achieved in developing methods enabling synthesis under very mild reaction conditions in the synthesis of iminium salts, which are intermediates, in the synthesis of cyano compounds from iminium salts, and in cyclization into pyridines.
(FR)
La présente invention concerne un nouveau procédé de production de dérivés de diarylpyridine, le but de la présente invention étant de fournir un nouveau procédé utile sur le plan industriel. L'invention concerne un nouveau procédé de synthèse de cycles pyridines sans utiliser de palladium, une base forte, ou une réaction à haute température. Le procédé fourni par la présente invention permet une synthèse dans des conditions de réaction très douces de sels d'iminium, qui sont des intermédiaires, dans la synthèse de composés cyano à partir de sels d'iminium, et dans la cyclisation en pyridines.
(JA)
本発明は、ジアリールピリジン誘導体の新規な製造方法に関し、工業的に有用で新規な方法を提供することを目的とする。 パラジウム、強塩基、および高温下での反応を用いない、ピリジン環の新規な合成方法を開発した。特に、中間体であるイミニウム塩の合成、イミニウム塩からシアノ化合物への合成、およびピリジンへの環化についても、極めて温和な反応条件で合成できる方法を開発することに成功した。
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