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1. WO2020008206 - HETEROCYCLIC SULFONAMIDE DERIVATIVES AND PHARMACEUTICAL USES THEREOF

Publication Number WO/2020/008206
Publication Date 09.01.2020
International Application No. PCT/GB2019/051903
International Filing Date 05.07.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4178
not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
04
having one double bond between ring members or between a ring member and a non-ring member
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
A61K 31/4164 (2006.01)
A61K 31/4178 (2006.01)
A61P 9/00 (2006.01)
A61P 25/00 (2006.01)
A61P 29/00 (2006.01)
A61P 37/00 (2006.01)
CPC
A61K 31/4164
A61K 31/4178
A61P 25/00
A61P 29/00
A61P 37/00
A61P 9/00
Applicants
  • METRION BIOSCIENCES LIMITED [GB/GB]; Suite 1, Riverside 3 Granta Park Great Abingdon CB21 6AD, GB
Inventors
  • ROGERS, Marc; GB
  • KIRBY, Robert; GB
  • SHOMI, Gakujun; GB
  • MATSUO, Takuya; GB
  • KOBAYASHI, Satoru; GB
  • KANAZAWA, Junichiro; GB
  • YAMAOKA, Nobutaka; GB
  • TORIZUKA, Makoto; GB
  • SUZAWA, Koichi; GB
Agents
  • GIBSON, Mark; GB
  • AITKEN, Elizabeth; GB
Priority Data
1811165.806.07.2018GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HETEROCYCLIC SULFONAMIDE DERIVATIVES AND PHARMACEUTICAL USES THEREOF
(FR) DÉRIVÉS DE SULFONAMIDE HÉTÉROCYCLIQUES ET LEURS UTILISATIONS PHARMACEUTIQUES
Abstract
(EN)
The invention relates to heterocyclic sulfonamide derivatives and their use in the treatment and prophylaxis of autoimmune, inflammatory, cardiovascular, neuronal, auditory, renal and metabolic mediated diseases, and to compositions containing said derivatives and processes for their preparation.
(FR)
L'invention concerne des dérivés de sulfonamide hétérocycliques et leur utilisation dans le traitement et la prophylaxie de maladies auto-immunes, inflammatoires, cardiovasculaires, neuronales, auditives, rénales et métaboliques, ainsi que des compositions contenant lesdits dérivés et des procédés pour leur préparation.
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