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1. WO2020007878 - CELLULAR AGGREGATES FOR USE IN VASCULARISATION THERAPY

Publication Number WO/2020/007878
Publication Date 09.01.2020
International Application No. PCT/EP2019/067769
International Filing Date 02.07.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
A61K 35/28 (2015.01)
C12N 5/0775 (2010.01)
CPC
A61K 35/00
C12N 2500/90
C12N 2501/11
C12N 2501/115
C12N 2501/165
C12N 2501/91
Applicants
  • UNIVERSIDAD DEL PAÍS VASCO - EUSKAL HERRIKO UNIBERTSITATEA [ES/ES]; OTRI, Edificio Rectorado C.Barrio Sarriena s/n 48940 LEIOA, ES
  • ACHUCARRO BASQUE CENTER FOR NEUROSCIENCE FUNDAZIOA [ES/ES]; Science Park of the UPV/EHU Sede Building, 3rd floor Barrio Sarriena, s/n 48940 LEIOA, ES
Inventors
  • PINEDA MARTÍ, José Ramón; ES
  • LUZURIAGA GONZÁLEZ, Jon; ES
  • UNDA RODRÍGUEZ, Fernando; ES
  • PASTOR ALONSO, Oier; ES
  • ENCINAS PÉREZ, Juan Manuel; ES
  • IBARRETXE BILBAO, Gaskon; ES
  • IRASTORZA EPELDE, Igor; ES
Agents
  • ZBM PATENTS - ZEA, BARLOCCI & MARKVARDSEN; Rambla Catalunya 123 08008 Barcelona, ES
Priority Data
18382492.903.07.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CELLULAR AGGREGATES FOR USE IN VASCULARISATION THERAPY
(FR) AGRÉGATS CELLULAIRES DESTINÉS À ÊTRE UTILISÉS DANS UNE THÉRAPIE DE VASCULARISATION
Abstract
(EN)
The present invention provides a serum-free endothelial cell differentiation culture medium comprising (a) a basal culture medium and (b) an endothelial cell differentiation combination of EGF,FGFand VEGF protein, wherein the amount of EGF is higher than the amount of FGF protein. The present invention further provides a process for the preparation of cellular aggregate suspensions comprising differentiated endothelial cells from dental stem cells using the serum-free medium, as well as the use of the resulting suspension in therapy.
(FR)
La présente invention concerne un milieu de culture de différenciation de cellules endothéliales exempt de sérum comprenant (a) un milieu de culture de base et (b) une combinaison de différenciation de cellules endothéliales de protéines EGF, FGF et VEGF, la quantité d'EGF étant supérieure à la quantité de protéine FGF. La présente invention concerne en outre un procédé de préparation de suspensions d'agrégats cellulaires comprenant des cellules endothéliales différenciées à partir de cellules souches dentaires à l'aide du milieu sans sérum, ainsi que l'utilisation de la suspension résultante en thérapie.
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