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1. WO2020007505 - PHARMACEUTICAL COMPOSITION COMPRISING AN IRON CHELATING AGENT AND METHOD FOR THE PREPARATION THEREOF

Publication Number WO/2020/007505
Publication Date 09.01.2020
International Application No. PCT/EP2019/025208
International Filing Date 03.07.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
A61K 9/20 (2006.01)
A61K 31/4196 (2006.01)
CPC
A61K 31/4196
A61K 47/26
A61K 9/2018
A61K 9/2031
A61K 9/2095
Applicants
  • PHARMATHEN S.A. [GR/GR]; 6, Dervenakion Str. 153 51 Pallini Attikis, GR
Inventors
  • KARAVAS, Evangelos; GR
  • KOUTRIS, Efthymios; GR
  • SAMARA, Vasiliki; GR
  • KOUTRI, Ioanna; GR
  • KALASKANI, Anastasia; GR
  • KIZIRIDI, Christina; GR
  • KAKOURIS, Andeas; GR
Priority Data
2018010030603.07.2018GR
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION COMPRISING AN IRON CHELATING AGENT AND METHOD FOR THE PREPARATION THEREOF
(FR) COMPOSITION PHARMACEUTIQUE COMPRENANT UN AGENT CHÉLATEUR DE FER ET SON PROCÉDÉ DE PRÉPARATION
Abstract
(EN)
The present invention relates to a stable pharmaceutical formulation in the form of tablet for oral administration comprising a therapeutically effective amount of an iron chelating agent, in particular Deferasirox in an amount higher than 60% by weight based on the total weight of the medicament and an effective amount of a non-ionic surfactant. It also relates to a process for the preparation thereof.
(FR)
La présente invention concerne une formulation pharmaceutique stable sous la forme d'un comprimé pour administration orale comprenant une quantité thérapeutiquement efficace d'un agent chélateur de fer, en particulier du déférasirox en quantité supérieure à 60% en poids sur la base du poids total du médicament, et une quantité efficace d'un tensioactif non ionique. L'invention concerne également un procédé de préparation de celle-ci.
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