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1. WO2020007355 - CRYSTAL FORMS OF THIAZOLE COMPOUND AND APPLICATION THEREOF

Publication Number WO/2020/007355
Publication Date 09.01.2020
International Application No. PCT/CN2019/094824
International Filing Date 05.07.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
54
Nitrogen and either oxygen or sulfur atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
20
for DNA viruses
22
for herpes viruses
C07D 417/12 (2006.01)
C07D 277/54 (2006.01)
A61K 31/426 (2006.01)
A61P 31/22 (2006.01)
CPC
A61K 31/426
A61P 31/22
C07D 277/54
C07D 417/12
Applicants
  • 南京明德新药研发有限公司 MEDSHINE DISCOVERY INC. [CN/CN]; 中国江苏省南京市 南京高新开发区高新路9号商务办公室218室 Room 218, No.9 Gaoxin Road, Gaoxin Development District Nanjing, Jiangsu 210032, CN
Inventors
  • 石卫华 SHI, Weihua; CN
  • 江志赶 JIANG, Zhigan; CN
  • 贺海鹰 HE, Haiying; CN
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE; 中国上海市 小木桥路681号外经大厦21楼 21st Floor SFECO Mansion 681 Xiaomuqiao Road Shanghai 200032, CN
Priority Data
201810738963.X06.07.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CRYSTAL FORMS OF THIAZOLE COMPOUND AND APPLICATION THEREOF
(FR) FORMES CRISTALLINES D'UN COMPOSÉ THIAZOLE ET UTILISATIONS ASSOCIÉES
(ZH) 噻唑类化合物的晶型及其应用
Abstract
(EN)
Disclosed by the present invention are a crystal form A of a compound represented by formula (I), a compound represented by formula (II) and a crystal form B thereof, as well as an application of the crystal form A of the compound represented by formula (I), the compound represented by formula (II) and the crystal form B thereof in the preparation of a drug for the treatment diseases associated with the herpes simplex virus.
(FR)
La présente invention concerne une forme cristalline A d'un composé représenté par la formule (I), un composé représenté par la formule (II) et une forme cristalline B de celui-ci, ainsi qu'une utilisation de la forme cristalline A du composé représenté par la formule (I), le composé représenté par la formule (II) et la forme cristalline B de celui-ci dans la préparation d'un médicament pour le traitement de maladies associées au virus de l'herpès simplex.
(ZH)
本发明公开了式(Ⅰ)化合物的A晶型,式(Ⅱ)化合物及其B晶型,以及式(Ⅰ)化合物的A晶型、式(Ⅱ)化合物及其B晶型在制备治疗单纯疱疹病毒相关疾病的药物的应用。
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