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1. WO2020007329 - POLYMORPH OF HDAC6-SELECTIVE INHIBITOR AND APPLICATION THEREOF

Publication Number WO/2020/007329
Publication Date 09.01.2020
International Application No. PCT/CN2019/094602
International Filing Date 03.07.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
443
containing a five-membered ring with oxygen as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C07D 405/04 (2006.01)
A61K 31/443 (2006.01)
A61P 35/00 (2006.01)
CPC
A61K 31/443
A61P 35/00
C07D 405/04
Applicants
  • 基石药业(苏州)有限公司 CSTONE PHARMACEUTICALS (SUZHOU) CO., LTD. [CN/CN]; 中国江苏省苏州市 苏州工业园区星湖街218号生物纳米园A1楼北座二楼E168单元 218 Xinghu St, Building A1 E168, Suzhou Industrial Park Suzhou, Jiangsu 215123, CN
  • 拓石药业(上海)有限公司 CSTONE PHARMACEUTICALS (SHANGHAI ) CO., LTD. [CN/CN]; 中国上海市 自由贸易试验区德堡路38号1幢2层211-20室 Room 211-20, 2F, Building 1, 38 Debao Road, Shanghai Pilot Free Trade Zone Shanghai 200000, CN
  • 基石药业 CSTONE PHARMACEUTICALS [GB/GB]; 开曼群岛大开曼岛西湾路802号芙蓉路格兰德展厅,邮政信箱编号31119 P. O. Box 31119, Grand Pavilion, Hibiscus Way, 802 West Bay Road, Grand Cayman KY1-1205, KY
Inventors
  • 郭强 GUO, Qiang; CN
  • 韦昌青 WEI, Changqing; CN
  • 肖瑶 XIAO, Yao; CN
  • 樊莉莉 FAN, Lili; CN
  • 钱文远 QIAN, Wenyuan; CN
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE; 中国上海市 小木桥路681号外经大厦21楼 21st Floor SFECO Mansion 681 Xiaomuqiao Road Shanghai 200032, CN
Priority Data
201810726102.X04.07.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) POLYMORPH OF HDAC6-SELECTIVE INHIBITOR AND APPLICATION THEREOF
(FR) POLYMORPHE D'INHIBITEUR SÉLECTIF DE HDAC6 ET SON APPLICATION
(ZH) HDAC6选择性抑制剂的晶型及其应用
Abstract
(EN)
Disclosed in the present invention are a polymorph A of a compound represented by formula (I), and an application thereof in preparation of drugs for treating HDAC6-associated diseases.
(FR)
La présente invention concerne un polymorphe A d'un composé représenté par la formule (I), et une application de celui-ci dans la préparation de médicaments pour le traitement de maladies associées à HDAC6.
(ZH)
本发明公开了式(Ⅰ)所示化合物的A晶型,及其在制备治疗HDAC6相关疾病的药物的应用。
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