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1. WO2020006596 - NEUROACTIVE STEROIDS AND METHODS OF PREPARATION

Publication Number WO/2020/006596
Publication Date 09.01.2020
International Application No. PCT/AU2019/050697
International Filing Date 03.07.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
7
Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
31
Reduction in general
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57
substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57
substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573
substituted in position 21, e.g. cortisone, dexamethasone, prednisone
C07J 7/00 (2006.01)
C07B 31/00 (2006.01)
A61K 31/57 (2006.01)
A61K 31/573 (2006.01)
CPC
A61K 31/57
A61K 31/573
C07B 31/00
C07J 7/00
C07J 7/002
C07J 7/008
Applicants
  • DRAWBRIDGE PHARMACEUTICALS PTY LTD [AU/AU]; 23 Milton Parade Malvern, Victoria 3144, AU
Inventors
  • EDMONDS, Ian; US
  • HESSLER, Edward J.; US
Agents
  • DAVIES COLLISON CAVE PTY LTD; Level 10, 301 Coronation Drive Milton, Queensland 4064, AU
Priority Data
62/693,54603.07.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEUROACTIVE STEROIDS AND METHODS OF PREPARATION
(FR) STÉROÏDES NEUROACTIFS ET PROCÉDÉS DE PRÉPARATION
Abstract
(EN)
Disclosed are neuroactive steroid anaesthetic agents, methods for their preparation and compositions comprising the same. The invention provides scaled up and/or GMP methods for preparing neuroactive steroids, such as alfaxalone, alfadolone and alfadolone acetate.
(FR)
L'invention concerne des agents anesthésiques stéroïdiens neuroactifs, leurs procédés de préparation et des compositions les comprenant. L'invention concerne des procédés mis à l'échelle et/ou GMP pour préparer des stéroïdes neuroactifs, tels que l'alfaxalone, l'alfadolone et l'acétate d'alfadolone.
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