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1. (WO2020006576) COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASES
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2020/006576 International Application No.: PCT/US2019/040211
Publication Date: 02.01.2020 International Filing Date: 01.07.2019
IPC:
C07K 16/28 (2006.01) ,C07K 16/46 (2006.01) ,A61K 39/00 (2006.01) ,A61K 39/395 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Applicants:
CITY OF HOPE [US/US]; 1500 E. Duarte Road Duarte, CA 91010-3000, US
Inventors:
CASIMIRO, Jose, Enrique Montero; US
ROEP, Bart, Otto; US
WILLIAMS, John, Charles; US
Agent:
HETZER, Claudia, H.; US
AZRIN, Linda, B.; US
ADAMS, Lisa; US
ALLISON, William, F.; US
AMENDT, Kevin, C.; US
Priority Data:
62/692,50929.06.2018US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASES
(FR) COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UNE MALADIE AUTO-IMMUNE
Abstract:
(EN) Provided herein are, inter alia, anti-CD6 antibody-growth factor complexes including an anti-CD6 antibody portion bound to a growth factor protein (e.g., EGF) through a linker, which may be cleavable by a protease (e.g., diabetic microenvironment specific protease). The compositions provided herein are, inter alia, usefule for the treatment of autoimmune diseases (e.g., type I diabetes).
(FR) La présente invention concerne, entre autres, des complexes anticorps anti-CD6-facteur de croissance comprenant une partie d'anticorps anti-CD6 liée à une protéine de facteur de croissance (par exemple, EGF) par l'intermédiaire d'un lieur, qui peut être clivable par une protéase (par exemple, une protéase spécifique du microenvironnement diabétique). Les procédés selon l'invention sont utiles, entre autres, pour le traitement du cancer et des maladies autoimunes (par exemple, le diabète de type I).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)