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1. WO2020006544 - HUMANIZED ANTIBODIES AGAINST HUMAN TIM-3 AND USES THEREOF

Publication Number WO/2020/006544
Publication Date 02.01.2020
International Application No. PCT/US2019/040029
International Filing Date 29.06.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
A61K 39/395 (2006.01)
C12N 15/13 (2006.01)
C07K 16/28 (2006.01)
C07K 16/30 (2006.01)
CPC
A61K 2039/505
A61K 31/675
A61K 39/39541
A61P 35/00
C07K 16/2803
C07K 2317/21
Applicants
  • DEVELOPMENT CENTER FOR BIOTECHNOLOGY; No.107, Ln. 130, Sec. 1, Academia Rd., Nangang Dist. Taipei, 11571, TW
  • DCB-USA LLC [US/US]; 1007 N. Orange Street, 9th Floor Wilmington, Delaware 19801, US
Inventors
  • YANG, Yu-Chen; TW
  • LI, Chia-Hua; TW
  • LIN, Shu-Hui; TW
  • TSAI, Ai-Hsuan; TW
  • WU, I-Jung; TW
  • TSAI, Hsien-Yu; TW
  • LAI, Szu-Liang; TW
  • LO, Mu-Shung; TW
  • LO, Yu-Hsun; TW
  • KUAN, Chien-Tsun; TW
Agents
  • LIANG LEGAL GROUP, PLLC; 6020 Annapolis Street Houston, Texas 77005, US
  • LIANG, T. Chyau; US
Priority Data
62/691,79329.06.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMANIZED ANTIBODIES AGAINST HUMAN TIM-3 AND USES THEREOF
(FR) ANTICORPS HUMANISÉS DIRIGÉS CONTRE LE TIM-3 HUMAIN ET LEURS UTILISATIONS
Abstract
(EN)
A humanized anti-human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) antibody, or a binding fragment thereof, wherein the antibody or the binding fragment includes a heavy-chain variable domain that comprises framework region sequences derived from a human immunoglobulin and the following complementarity determining region (CDR) sequences: HCDRI (SEQ ID NO: 3), HCDR2 (SEQ ID NO: 4), HCDR3 (SEQ ID NO: 5), and a light-chain variable domain that includes framework region sequences from a human immunoglobulin and the following CDR sequences: LCDR1 (SEQ ID NO: 6), LCDR2 (SEQ ID NO: 7), and LCDR3 (SEQ ID NO: 8).
(FR)
L'invention concerne un anticorps de domaine des immunoglobulines des lymphocytes T et de domaine de mucine 3 (TIM-3) anti-humain humanisé, ou son fragment de liaison, l'anticorps ou le fragment de liaison comprenant un domaine variable de chaîne lourde qui comporte des séquences de région de structure dérivées d'une immunoglobuline humaine et les séquences de région de détermination de complémentarité (CDR) suivantes : HCDRI (SEQ ID NO: 3), HCDR2 (SEQ ID NO: 4), HCDR3 (SEQ ID NO: 5), et un domaine variable de chaîne légère qui comprend des séquences de région de structure dérivées d'une immunoglobuline humaine et les séquences CDR suivantes : LCDR1 (SEQ ID NO: 6), LCDR2 (SEQ ID NO: 7), et LCDR3 (SEQ ID NO: 8).
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