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1. (WO2020006539) COMPOSITIONS FOR DRUG DELIVERY AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2020/006539 International Application No.: PCT/US2019/040021
Publication Date: 02.01.2020 International Filing Date: 29.06.2019
IPC:
A61K 35/12 (2015.01) ,A61K 35/14 (2015.01) ,A61K 35/19 (2015.01) ,C12N 5/078 (2010.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
[IPC code unknown for A61K 35/19]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
Applicants:
PLATELET BIOGENESIS, INC. [US/US]; 325 Vassar Street Suite 2A Cambridge, Massachusetts 02139, US
Inventors:
THON, Jonathan N.; US
DYKSTRA, Brad; US
SMITH, Brenden William; US
Agent:
FAYERBERG, Roman; US
Priority Data:
62/692,27729.06.2018US
Title (EN) COMPOSITIONS FOR DRUG DELIVERY AND METHODS OF USE THEREOF
(FR) COMPOSITIONS POUR L'ADMINISTRATION DE MÉDICAMENTS ET LEURS MÉTHODES D'UTILISATION
Abstract:
(EN) Methods for producing megakaryocytes and platelets derived from inducible pluripotent stem cells and comprising a therapeutic agent are provided. The present disclosure further provides methods and compositions for loading a platelet or a megakaryocyte with a therapeutic agent and for genetically modifying a platelet or a megakaryocyte to express an agent.
(FR) L'invention concerne des procédés de production de mégacaryocytes et de plaquettes dérivés de cellules souches pluripotentes inductibles et comprenant un agent thérapeutique. La présente invention concerne en outre des procédés et des compositions pour charger une plaquette ou un mégacaryocyte avec un agent thérapeutique et pour modifier génétiquement une plaquette ou un mégacaryocyte pour exprimer un agent.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)