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1. (WO2020006504) ANABOLIC TARGETING STEM CELL GENE THERAPY FOR OSTEOPOROSIS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2020/006504 International Application No.: PCT/US2019/039969
Publication Date: 02.01.2020 International Filing Date: 28.06.2019
IPC:
A61K 38/17 (2006.01) ,A61K 38/18 (2006.01) ,A61K 38/30 (2006.01) ,A61K 48/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
30
Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
LOMA LINDA UNIVERSITY [US/US]; 11145 Anderson Street Loma Linda, California 92350, US
FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE [US/US]; 11175 Campus Street Suite 11120 Loma Linda, California 92350, US
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF VETERANS AFFAIRS [US/US]; 810 Vermont Avenue NW Washington, District of Columbia 20420, US
Inventors:
XIAOBING, Zhang; US
BAYLINK, David; US
CHEN, Wanqui; US
LAU, Kin-Hing William; US
Agent:
YAO, Zhengzheng; US
APPLE, Randolph T.; US
Priority Data:
62/691,54128.06.2018US
Title (EN) ANABOLIC TARGETING STEM CELL GENE THERAPY FOR OSTEOPOROSIS
(FR) THÉRAPIE GÉNIQUE DE CELLULES SOUCHES À CIBLAGE ANABOLIQUE CONTRE L'OSTÉOPOROSE
Abstract:
(EN) In one aspect, anabolic agent fusion proteins and compositions comprising anabolic agent fusion proteins are provided. In some embodiments, the anabolic agent fusion protein comprises a platelet derived growth factor (PDGF) or a fibroblast growth factor (FGF) and an Asp-Ser-Ser tripeptide (DSS) repeat sequence. In another aspect, methods of promoting bone growth and methods of treating a fracture using anabolic agent fusion proteins and compositions comprising anabolic agent fusion proteins are provided.
(FR) Selon un aspect, l'invention concerne des protéines de fusion d'agents anaboliques et des compositions comprenant des protéines de fusion d'agents anaboliques. Dans certains modes de réalisation, la protéine de fusion d'agent anabolique comprend un facteur de croissance dérivé des plaquettes (PDGF) ou un facteur de croissance des fibroblastes (FGF) et une séquence répétée de tripeptide Asp-Ser-Ser (DSS). Selon un autre aspect, l'invention concerne des procédés de promotion de la croissance osseuse et des méthodes de traitement d'une fracture à l'aide de protéines de fusion d'agents anaboliques et de compositions comprenant des protéines de fusion d'agents anaboliques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)