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1. WO2020006432 - FUSED TRICYCLIC HETEROCYCLE COMPOUNDS AND THERAPEUTIC USES THEREOF

Publication Number WO/2020/006432
Publication Date 02.01.2020
International Application No. PCT/US2019/039860
International Filing Date 28.06.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
A61K 31/4164 (2006.01)
C07D 403/14 (2006.01)
CPC
A61K 31/4164
C07D 487/16
C07D 498/16
Applicants
  • ETERNITY BIOSCIENCE INC. [US/US]; 6 Cedarbrook Drive Cranbury, NJ 08512, US
Inventors
  • LIU, Dong; US
  • CHEN, Lei; US
  • ZHUANG, Linghang; US
  • LI, Puhui; US
  • ZHANG, Xinzhu; US
  • SONG, Chunying; US
  • MILLER, Matthew; US
  • HU, Qiyue; CN
  • YAN, Yuna; CN
  • HE, Feng; CN
  • TAO, Weikang; US
Agents
  • LIU, Wansheng, Jerry; US
  • BARRISON, Flynn; US
  • HALPERN, Nancy, E.; US
  • CHEN, Joe; US
  • BUTCH, Peter, J.; US
Priority Data
62/691,20828.06.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FUSED TRICYCLIC HETEROCYCLE COMPOUNDS AND THERAPEUTIC USES THEREOF
(FR) COMPOSÉS HÉTÉROCYCLIQUES TRICYCLIQUES FUSIONNÉS ET LEURS UTILISATIONS THÉRAPEUTIQUES
Abstract
(EN)
This application discloses a new class of fused tricyclic heterocycles of formula (I), preparation methods thereof, pharmaceutical compositions comprising these compounds, and pharmaceutically acceptable salts, solvates, or prodrugs thereof, and their uses for the treatment of diseases in which modulation of STING is beneficial, for example, cancers, pre-cancerous disorders, and viral infections.
(FR)
L'invention concerne une nouvelle classe d'hétérocycles tricycliques fusionnés de formule (I), leurs procédés de préparation, des compositions pharmaceutiques comprenant ces composés, et des sels pharmaceutiquement acceptables, des solvates, ou des promédicaments de ceux-ci, et leurs utilisations pour le traitement de maladies dans lesquelles la modulation de STING est bénéfique, par exemple, les cancers, les troubles précancéreux et les infections virales.
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