Processing

Please wait...

Settings

Settings

1. WO2020006325 - METHODS FOR TREATING OR PREVENTING CONFORMATION DISEASES AND METHODS FOR DRUG SCREENING

Publication Number WO/2020/006325
Publication Date 02.01.2020
International Application No. PCT/US2019/039643
International Filing Date 28.06.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/00 (2006.01)
A61P 25/14 (2006.01)
CPC
A61K 31/00
A61P 25/00
A61P 25/14
Applicants
  • GARAGE BRAIN SCIENCE CO., LTD [CN/CN]; No. 7, Aly. 2, Ln. 166, Shuren Rd., Wufeng Dist. Taichung City, 413, TW
  • TSAI, Tsung-Yu [US/US]; US
Inventors
  • TSAI, Tsung-Yu; US
  • CHANG, Hsiang-Yu; TW
  • WANG, I-Fan; TW
Agents
  • MUNCY, GEISSLER, OLDS & LOWE, P.C.; 4000 Legato Rd., Suite 310 Fairfax, Virginia 22033, US
Priority Data
62/691,14228.06.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR TREATING OR PREVENTING CONFORMATION DISEASES AND METHODS FOR DRUG SCREENING
(FR) MÉTHODES DE TRAITEMENT OU DE PRÉVENTION DE MALADIES CONFORMATIONNELLES ET PROCÉDÉS DE CRIBLAGE DE MÉDICAMENT
Abstract
(EN)
Described herein are pharmaceutical compositions and methods for treating and preventing conformational diseases such as, TDP-43 proteinopathies, SMA, amyloid positive cancer, normal and premature aging. Also disclosed are in vitro screening methods for screening a therapeutic candidate to treat conformation diseases, by measuring the expression level of prion-like folding of aggregation-prone proteins or a P53 aggregate.
(FR)
L'invention concerne des compositions pharmaceutiques et des méthodes de traitement et de prévention de maladies conformationnelles telles que les protéinopathies de TDP -43, le SMA, le cancer amyloïde, le vieillissement normal et prématuré. L'invention concerne également des procédés de criblage in vitro pour cribler un candidat thérapeutique pour traiter des maladies conformationnelles, par mesure du niveau d'expression de repliement de type prion de protéines sujettes à l'agrégation ou d'un agrégat de P53.
Latest bibliographic data on file with the International Bureau