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1. WO2020006296 - PROTEASOME ACTIVITY ENHANCING COMPOUNDS

Publication Number WO/2020/006296
Publication Date 02.01.2020
International Application No. PCT/US2019/039600
International Filing Date 27.06.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
08
Bridged systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
451
Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02
containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane; Cyclic acetals thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
451
Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02
containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring systems, e.g. tropane; Cyclic acetals thereof
04
with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.02,4] nonane ring system
06
Oxygen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025
not condensed and containing further heterocyclic rings, e.g. cromakalim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
405
Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
C07D 405/14 (2006.01)
C07D 491/08 (2006.01)
C07D 403/06 (2006.01)
C07D 403/14 (2006.01)
C07D 417/14 (2006.01)
C07D 451/02 (2006.01)
CPC
A61P 25/00
A61P 25/16
A61P 25/28
C07D 403/06
C07D 403/14
C07D 405/14
Applicants
  • PROTEOSTASIS THERAPEUTICS, INC. [US/US]; 80 Guest Street, Suite 500 Boston, Massachusetts 02135, US
Inventors
  • CULLEN, Matthew; US
  • BASTOS, Cecilia M.; US
  • PARKS, Daniel; US
  • MUNOZ, Benito; US
Agents
  • ALLEN, Derick E.; US
  • AMODIO, Lucas M.; US
  • ATKINS, Bruce T.; US
  • BLOCK, Zachary J.; US
  • BRENNAN, Patrick E.; US
  • COYLE, Patrick J.; US
  • FITZGERALD, Daniel M.; US
  • FLOREK, Erin M.; US
  • GOFF, Christopher M.; US
  • HARPER, James D.; US
  • HARPER, Jesse S.; US
  • HEINEN JR., James M.; US
  • HENSON, James W.; US
  • HILMERT, Laura J.; US
  • KEPPEL, Nicholas A.; US
  • LONGMEYER, Michael H.; US
  • MUELLER, Jacob R.; US
  • MUNSELL, Michael G.; US
  • POLAND, Eric G.; US
  • RASCHE, Patrick W.; US
  • REESER III, Robert B.; US
  • SCHUTH, Richard A.; US
  • SNIDER, Josh C.; US
  • TRUITT, Tracey S.; US
  • VANDER MOLEN, Michael J.; US
  • WULLER, Adam R.; US
  • ZYCHLEWICZ, William J.; US
  • BENNETT, Rachel; US
  • BRACCIANO, Daniel D.; US
  • BUTLER, Christopher H.; US
  • KU, Deborah S.; US
  • MARTINEZ, Alexandra; US
  • SCHNEIDERJOHN, Robert L.; US
Priority Data
62/690,56327.06.2018US
62/690,56527.06.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROTEASOME ACTIVITY ENHANCING COMPOUNDS
(FR) COMPOSÉS AMÉLIORANT L'ACTIVITÉ DU PROTÉASOME
Abstract
(EN)
The present invention is directed towards compounds having the Formula (lb) or the Formulae (III) and pharmaceutically acceptable salts, solvates and clathrates thereof, compositions thereof, as well as towards the use of said compounds in methods for the treatment of a condition associated with a dysfunction in proteostasis.
(FR)
La présente invention concerne des composés ayant la formule (lb) ou les formules (III) et leurs sels, solvates et clathrates pharmaceutiquement acceptables, des compositions de ceux-ci, ainsi que l'utilisation desdits composés dans des procédés pour le traitement d'une affection associée à un dysfonctionnement dans la protéostase.
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