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1. (WO2020006229) COMPOUNDS FOR INHIBITION OF INFLAMMATION
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2020/006229 International Application No.: PCT/US2019/039499
Publication Date: 02.01.2020 International Filing Date: 27.06.2019
IPC:
A61K 31/10 (2006.01) ,A61K 31/27 (2006.01) ,C07C 323/00 (2006.01) ,C07C 323/23 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
095
Sulfur, selenium or tellurium compounds, e.g. thiols
10
Sulfides; Sulfoxides; Sulfones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
27
of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
23
containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
Applicants:
CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 55 Shattuck Street Boston, Massachusetts 02115, US
Inventors:
WU, Hao; US
LIEBERMAN, Judy; US
HU, Jun; US
LIU, Xing; US
Agent:
IGNATENKO, Vasily A.; US
GARCIA, Todd E.; US
Priority Data:
62/690,78827.06.2018US
Title (EN) COMPOUNDS FOR INHIBITION OF INFLAMMATION
(FR) COMPOSÉS POUR L'INHIBITION DE L'INFLAMMATION
Abstract:
(EN) The present application provides chemical compounds useful, for example, in inhibiting gasdermin pore formation in a cell, inhibiting inflammasome-mediated death of a cell (pyroptosis); inhibiting cytokine secretion from a cell, inhibiting an inflammatory caspase in a cell, and/or covalently reacting with a cysteine of a gasdermin protein in a cell. These compounds are also useful in treating or preventing diseases or conditions in which inflammasome activation is implicated in pathogenesis. One example of such disease or condition is sepsis.
(FR) La présente invention concerne des composés chimiques utiles, par exemple, dans l'inhibition de la formation de pores par les gasdermines dans une cellule, l'inhibition de la mort médiée par les inflammasomes d'une cellule (pyroptose); l'inhibition de la sécrétion de cytokine par une cellule, l'inhibition d'une caspase inflammatoire dans une cellule, et/ou la réaction covalente avec une cystéine d'une protéine gasdermine dans une cellule. Ces composés sont également utiles dans le traitement ou la prévention de maladies ou d'affections dans lesquels l'activation de l'inflammasome est impliquée dans la pathogenèse. Un exemple d'une telle maladie ou affection est une sepsie.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)