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1. WO2020006175 - METHODS AND COMPOSITIONS RELATING TO PERSONALIZED PAIN MANAGEMENT

Publication Number WO/2020/006175
Publication Date 02.01.2020
International Application No. PCT/US2019/039411
International Filing Date 27.06.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
48
involving transferase
A61K 31/19 (2006.01)
C12Q 1/34 (2006.01)
C12Q 1/48 (2006.01)
CPC
A61K 31/245
A61K 31/706
A61K 31/7068
C12Q 1/34
C12Q 1/48
Applicants
  • CHILDREN'S HOSPITAL MEDICAL CENTER [US/US]; 3333 Burnet Avenue, ML 7032 Cincinnati, OH 45229, US
Inventors
  • CHIDAMBARAN, Vidya; US
  • JI, Hong; US
Agents
  • LIBERTO, Muriel; US
  • REEVES, Andrew, R.; US
Priority Data
62/691,01928.06.2018US
62/731,54814.09.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS RELATING TO PERSONALIZED PAIN MANAGEMENT
(FR) PROCÉDÉS ET COMPOSITIONS DE GESTION PERSONNALISÉE DE LA DOULEUR
Abstract
(EN)
The disclosure relates to methods for pain management in the perioperative context, particularly through the use of one or more biomarkers such as the DNA methylation status in genes of the GABA receptor signaling pathway or the dopamine-DARPP32 feedback in cAMP signaling pathway, or both; or the expression of one or more cytokines in peripheral blood, as biomarkers for increased susceptibility to perioperative pain and/or increased risk for developing chronic postsurgical pain (CPSP).
(FR)
La présente invention concerne des procédés de gestion de la douleur dans le contexte péri-opératoire, particulièrement à l'aide d’un ou plusieurs biomarqueurs tels que l’état de méthylation de l’ADN dans des gènes de la voie de signalisation du récepteur GABA ou la rétroaction de la dopamine-DARPP32 dans la voie de signalisation de l’AMPc, ou les deux ; ou l’expression d’une ou plusieurs cytokines dans le sang périphérique, comme biomarqueurs pour la sensibilité accrue à la douleur péri-opératoire et/ou le risque accru de développer une douleur post-chirurgicale chronique (CPSP).
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