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1. (WO2020006132) GAPPED AND TUNABLE REPEAT UNITS FOR USE IN GENOME EDITING AND GENE REGULATION COMPOSITIONS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2020/006132 International Application No.: PCT/US2019/039326
Publication Date: 02.01.2020 International Filing Date: 26.06.2019
IPC:
C12Q 1/68 (2018.01) ,C12N 9/22 (2006.01) ,C07K 14/195 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
22
Ribonucleases
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
Applicants:
ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES [US/US]; 2211 Elliot avenue 4th Floor Seattle, Washington 98121, US
URNOV, Fyodor [US/US]; US
STAMATOYANNOPOULOS, John A. [US/US]; US
Inventors:
URNOV, Fyodor; US
STAMATOYANNOPOULOS, John A.; US
Agent:
CHANDRA, Shweta; US
Priority Data:
62/690,89027.06.2018US
62/716,21708.08.2018US
62/852,15823.05.2019US
Title (EN) GAPPED AND TUNABLE REPEAT UNITS FOR USE IN GENOME EDITING AND GENE REGULATION COMPOSITIONS
(FR) MOTIFS DE RÉPÉTITION AJUSTABLES ET À BRÈCHE DESTINÉS À ÊTRE UTILISÉS DANS DES COMPOSITIONS D'ÉDITION DE GÉNOME ET DE RÉGULATION DE GÈNES
Abstract:
(EN) Provided herein are DNA binding domains comprising a plurality of repeat units, wherein each repeat unit is expanded or contracted in length. Also provided herein are DNA binding domains comprising a plurality of repeat units, wherein each repeat unit is separated from a neighboring repeat unit by a linker. In certain aspects, the linker includes a recognition site. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a TALE protein. The TALE protein may be a Xanthomonas TALE protein.
(FR) L'invention concerne des domaines de liaison à l'ADN comprenant une pluralité de motifs de répétition, la longueur de chaque motif de répétition pouvant être étendue ou contractée. L'invention concerne également des domaines de liaison à l'ADN comprenant une pluralité de motifs de répétition, chaque motif de répétition étant séparé d'un motif de répétition voisin par un lieur. Selon certains aspects, le lieur comprend un site de reconnaissance. L'invention concerne également des protéines de liaison à l'ADN qui comprennent un fragment de séquence de coiffe N-terminale d'une protéine TALE. La protéine TALE peut être une protéine TALE de Xanthomonas.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)