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1. WO2020006131 - NUCLEASES FOR GENOME EDITING

Publication Number WO/2020/006131
Publication Date 02.01.2020
International Application No. PCT/US2019/039325
International Filing Date 26.06.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
C07K 14/47 (2006.01)
C12N 9/14 (2006.01)
C12N 9/16 (2006.01)
C12N 15/62 (2006.01)
CPC
C07K 2319/80
C07K 2319/81
C12N 15/01
C12N 9/22
Applicants
  • ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES [US/US]; 2211 Elliot avenue 4th Floor Seattle, Washington 98121, US
  • STAMATOYANNOPOULOS, John A. [US/US]; US
  • URNOV, Fyodor [US/US]; US
  • PEARL, Jocelynn [US/US]; US
  • THOMAS, Sean [US/US]; US
Inventors
  • STAMATOYANNOPOULOS, John A.; US
  • URNOV, Fyodor; US
  • PEARL, Jocelynn; US
  • THOMAS, Sean; US
Agents
  • CHANDRA, Shweta; US
Priority Data
62/690,90327.06.2018US
62/716,22908.08.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NUCLEASES FOR GENOME EDITING
(FR) NUCLÉASES POUR ÉDITION GÉNOMIQUE
Abstract
(EN)
DNA cleaving enzymes are disclosed. The DNA cleaving enzymes are fused to a heterologous DNA binding domain that is designed to bind to a target nucleic acid sequence. Nucleic acids and expression cassettes encoding the DNA cleaving enzymes are also provided. Methods for genome editing using the DNA cleaving enzymes, fusion proteins, and compositions thereof are disclosed herein.
(FR)
L'invention concerne des enzymes de clivage d'ADN. Les enzymes de clivage d'ADN sont fusionnées à un domaine de liaison d'ADN hétérologue qui est conçu pour se lier à une séquence d'acides nucléiques cible. L'invention concerne également des acides nucléiques et des cassettes d'expression codant pour les enzymes de clivage d'ADN. L'invention concerne en outre des procédés d'édition génomique à l'aide des enzymes de clivage d'ADN, des protéines de fusion et des compositions associées.
Latest bibliographic data on file with the International Bureau