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1. WO2020006126 - NUCLEIC ACID BINDING DOMAINS AND METHODS OF USE THEREOF

Publication Number WO/2020/006126
Publication Date 02.01.2020
International Application No. PCT/US2019/039318
International Filing Date 26.06.2019
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
C12N 15/09 (2006.01)
C12N 15/63 (2006.01)
C12N 15/79 (2006.01)
C12N 15/85 (2006.01)
CPC
C12N 15/09
C12N 15/102
C12N 15/63
C12N 15/79
C12N 15/85
C12N 9/22
Applicants
  • ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES [US/US]; 2211 Elliot avenue 4th Floor Seattle, Washington 98121, US
  • STAMATOYANNOPOULOS, John A. [US/US]; US
  • URNOV, Fyodor [US/US]; US
  • THOMAS, Sean [US/US]; US
Inventors
  • STAMATOYANNOPOULOS, John A.; US
  • URNOV, Fyodor; US
  • THOMAS, Sean; US
Agents
  • CHANDRA, Shweta; US
Priority Data
62/690,88827.06.2018US
62/694,23905.07.2018US
62/716,14708.08.2018US
62/852,13423.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NUCLEIC ACID BINDING DOMAINS AND METHODS OF USE THEREOF
(FR) DOMAINES DE LIAISON D’ACIDE NUCLÉIQUE ET LEURS PROCÉDÉS D’UTILISATION
Abstract
(EN)
Provided herein are polypeptides, compositions comprising the polypeptides and methods for genome editing and gene regulation (e.g., activation and/or repression) using the polypeptides or the compositions comprising the polypeptides, such as, DNA binding domains derived from the genus of Ralstonia. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a TALE protein, such as, a Xanthomonas TALE protein. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a DNA binding protein derived from bacteria of the genus Ralstonia.
(FR)
La présente invention concerne des polypeptides, des compositions comprenant les polypeptides et des procédés d’édition de génome et de régulation de gène (par exemple, d’activation et/ou de répression) en utilisant les polypeptides ou les compositions comprenant les polypeptides, tels que, des domaines de liaison à l’ADN dérivés du genre de Ralstonia. L’invention concerne également des protéines de liaison d’ADN qui comprennent un fragment de la séquence N-cap d’une protéine TALE, telle que, une protéine de Xanthomonas TALE. L’invention concerne également des protéines de liaison d’ADN qui comprennent un fragment de la séquence N-cap d’une protéine de liaison d’ADN à partir de bactéries du genre Ralstonia.
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