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1. WO2020005992 - THERAPY AND PREVENTION OF PRION PROTEIN COMPLEX INFECTIONS IN NON-HUMAN ANIMALS

Publication Number WO/2020/005992
Publication Date 02.01.2020
International Application No. PCT/US2019/039060
International Filing Date 25.06.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
436
the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
65
Tetracyclines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A61K 31/436 (2006.01)
A61K 31/65 (2006.01)
A61P 31/04 (2006.01)
CPC
A61K 2300/00
A61K 31/436
A61K 31/65
A61K 45/06
A61K 9/00
A61K 9/0053
Applicants
  • ATIBA, Joshua O. [US/US]; US
  • SEREBOFF, Steven C. [US/US]; US
Inventors
  • ATIBA, Joshua O.; US
  • SEREBOFF, Steven C.; US
Agents
  • TAMSUT, Brian S.; US
  • GOLDSTEIN, Mark A.; US
  • HARRIS, Michael; US
  • GUNTHER, John; US
  • PEARCE, Jonathan; US
  • DOSSMAN, Nikki M.; US
  • CUMBERBATCH, Guy L.; US
  • GAZ, Angelo; US
  • SEREBOFF, Steven C.; US
Priority Data
16/151,19303.10.2018US
62/690,73627.06.2018US
62/691,91029.06.2018US
62/714,01202.08.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERAPY AND PREVENTION OF PRION PROTEIN COMPLEX INFECTIONS IN NON-HUMAN ANIMALS
(FR) THÉRAPIE ET PRÉVENTION D'INFECTIONS À COMPLEXE PROTÉIQUE DE TYPE PRION CHEZ DES ANIMAUX NON HUMAINS
Abstract
(EN)
There are disclosed therapies and preventions of prion protein complex infections. The transcription of the amyloid precursor protein gene and PrP gene and the RNA transcript are the rate-limiting steps and are most susceptible for blockage and control of the process of amyloid protein formation and PrPsc formation. Thus, therapies and prevention regimes for prion protein complex infections interrupt this process at the level of DNA transcription to RNA, RNA transport to the mitochondrion for protein synthesis and deposition in the cerebral cortex neurons.
(FR)
L'invention concerne des thérapies et des moyens de prévention d'infections à complexe protéique de type prion. La transcription du gène de la protéine précurseur de l'amyloïde et du gène PrP et l’obtention de l'ARN transcrit sont les étapes cinétiquement limitantes et sont les plus susceptibles de bloquer et de réguler le processus de formation de la protéine amyloïde et de formation de PrPsc. Ainsi, des thérapies et des régimes de prévention d’infections à complexe protéique de type prion permettent d’interrompre ce processus au niveau de la transcription de l'ADN en ARN, du transport de l'ARN vers la mitochondrie pour la synthèse protéique et le dépôt dans les neurones du cortex cérébral.
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